The Promise of Genomics and Proteomics in Immunotoxicology and Immunopharmacology

Details

• Personal Author:
  Holladay SD ; Luster MI ; Prater MR ; Pruett SB ; Yucesoy, Berran
• Description:
  Genomics, including gene expression profiling (transcriptomics) and evaluation of SNPs, have been used in immunotoxicology studies to a limited extent. The primary value of high throughput microarray technology has been the identification of potential mechanisms of immunotoxicant action. Further implementation of genomic and proteomic methodology may serve to move immunotoxicology into the arena of systems biology. This approach could be beneficial with regard to mechanistic and screening applications and could also reveal new information about immune function. Similarly, data already available indicate that SNPs will be quite relevant in immunotoxicology and immunopharmacology. Findings that SNPs of immune-related proteins have an impact on the development of beryllium disease and silicosis suggest that SNPs may explain much of the daunting diversity of human responses to environmental and pharmaceutical agents. Proteomics involves the use of a wide array of methods, some of which can be conducted in a high throughput mode and are remarkably sensitive. Because proteins are the ultimate mediators of function in cells and organisms, proteomics will be a necessary component of any systematic effort to understand the mechanism of action of drugs or chemicals on the immune system. In conjunction with gene expression analysis, such studies can reveal whether the test article acts at the level of transcription or translation (or post-translationally). The development of "user friendly" mass produced methodologies, such as protein microarrays, is not as far along as in the case of genomics, but the potential uses of proteomics are similar to those mentioned already for transcription profiling. [Description provided by NIOSH]
• Subjects:
  Biological Factors Biological Products Biopharmaceutics Environmental Health Genetics Immune System Occupational Health Pharmacies Safety
• Keywords:
  Biological-agents Biological-effects Biological-factors Biological-systems Environmental-factors Genes Genetic-factors Genotoxic-effects Genotoxicity Immune-reaction Immune-system Immunochemistry Immunology Immunotoxins Pharmaceutical-industry Pharmaceuticals Pharmacodynamics Protein-biochemistry Protein-biosynthesis Protein-synthesis Proteins

  More +
• ISBN:
  9780849337901
• Publisher:
  CRC Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  79-95
• NIOSHTIC Number:
  nn:20034786
• Citation:
  Immunotoxicology and immunopharmacology, 3rd edition. Luebke R, House R, Kimber I, eds. Boca Raton, FL: CRC Press, 2006 Dec; :79-95
• Editor(s):
  Luebke R; House R; Kimber I
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  False
• Source Full Name:
  Immunotoxicology and immunopharmacology, 3rd edition
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7a75e842a6efc7a56798e8f33ad4aeef15608c13b93061c5c35ea7a0e20f2a31f936de8867675f503e5aae6efc0b6205145517a6b9b5bf5cb2ba0d393f3ebc48
• Download URL:
  https://stacks.cdc.gov/view/cdc/186864/cdc_186864_DS1.pdf
• File Type:
  [PDF - 4.37 MB ]