Description and Nomenclature of Neisseria meningitidis Capsule Locus

Harrison, Odile B.; Claus, Heike; Jiang, Ying; Bennett, Julia S.; Bratcher, Holly B.; Jolley, Keith A.; Corton, Craig; Care, Rory; Poolman, Jan T.; Zollinger, Wendell D.; Frasch, Carl E.; Stephens, David S.; Feavers, Ian; Frosch, Matthias; Parkhill, Julian; Vogel, Ulrich; Quail, Michael A.; Bentley, Stephen D.; Maiden, Martin C.J.

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Description and Nomenclature of Neisseria meningitidis Capsule Locus

Supporting Files Public Domain

Apr 2013
By Harrison, Odile B. ; Claus, Heike ; Jiang, Ying ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Harrison, Odile B. ; Claus, Heike ; Jiang, Ying ; Bennett, Julia S. ; Bratcher, Holly B. ; Jolley, Keith A. ; Corton, Craig ; Care, Rory ; Poolman, Jan T. ; Zollinger, Wendell D. ; Frasch, Carl E. ; Stephens, David S. ; Feavers, Ian ; Frosch, Matthias ; Parkhill, Julian ; Vogel, Ulrich ; Quail, Michael A. ; Bentley, Stephen D. ; Maiden, Martin C.J.
Description:

Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity. Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps. The use of multiple names for some of the genes involved in capsule synthesis, combined with the need for rapid diagnosis of serogroups commonly associated with invasive meningococcal disease, prompted a requirement for a consistent approach to the nomenclature of capsule genes. In this report, a comprehensive description of all N. meningitidis serogroups is provided, along with a proposed nomenclature, which was presented at the 2012 XVIIIth International Pathogenic Neisseria Conference.
Subjects:

Bacteria Bacterial Capsules Capsule Chromosomes, Bacterial Genes, Bacterial Genetic Loci Humans Magnetic Resonance Spectroscopy Meningococcal Infections Multigene Family Neisseria Meningitidis Nomenclature Polymerase Chain Reaction Polysaccharides, Bacterial Research Serogroup Serotyping Terminology As Topic Virulence
Source:

Emerg Infect Dis. 19(4):566-573.
Document Type:

Journal Article
Volume:

19
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:6e1754ef0494208dd224283633c6698d954296f4bbfe5e2cfa8e6e707e67b693
Download URL:

https://stacks.cdc.gov/view/cdc/18686/cdc_18686_DS1.pdf
File Type:

[PDF - 500.39 KB ]

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