Pharmacologic Effects of Grain Weevil Extract on Isolated Guinea Pig Tracheal Smooth Muscle

Details

• Personal Author:
  Arumugam U ; Castranova, Vincent ; Chiarelli A ; Goswami S ; Schachter EN ; Whitmer M ; Zuskin E
• Description:
  The grain weevil, an insect (pest) that infects grain, is a frequent contaminant of processed wheat, and its presence may contribute to respiratory abnormalities in grain workers. We studied the in vitro effects of an extract of grain weevil (GWE) on airway smooth muscle. Pharmacologic studies included in vitro challenge of guinea pig trachea with GWE, in parallel organ baths, pretreated with mediator-modifying agents or a control solution. Dose-related contractions of nonsensitized guinea pig trachea (GPT) were demonstrated using this extract. Pharmacologic studies were performed by pretreating guinea pig tracheal tissue with drugs known to modulate smooth muscle contraction: atropine, indomethacin, pyrilamine, acivicin, NDGA, BPB, TMB8, captopril, and capsaicin. Atropine, pyrilamine, BPB, and capsaicin significantly reduced the contractile effects of the extract at most of the challenge doses (p < 0.01 or p < 0.05). Inhibition of GWE-induced contraction by blocking of other mediators was less complete. We suggest that GWE causes dose-related airway smooth muscle constriction of the GPT by nonimmunologic mechanisms involving a variety of airway mediators and possibly cholinergic receptors. [Description provided by NIOSH]
• Subjects:
  Agriculture Farmers Insecta Irritants Laboratories Lung Occupational Health Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Safety

  More +
• Keywords:
  Agricultural-industry Agricultural-workers Airway-resistance Breathing Breathing-zone Contaminated-food Dose-response Insects Laboratory-animals Laboratory-testing Lung-irritants Pharmacodynamics Pharmacology Respiratory-hypersensitivity Respiratory-irritants Respiratory-system-disorders

  More +
• ISSN:
  0341-2040
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  317-321
• Volume:
  186
• Issue:
  5
• NIOSHTIC Number:
  nn:20034635
• Citation:
  Lung 2008 Oct; 186(5):317-321
• Contact Point Address:
  E. Neil Schachter, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574
• Email:
  neil.schachter@mssm.edu
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Lung
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cafdff919d4d543eb7a8d123b0c1752f301c70aa9d66df0bac6ed141e773dce45148525425dea7a26ca74a15fcf308f730eae8da727bbf395ad837c6165064ca
• Download URL:
  https://stacks.cdc.gov/view/cdc/186772/cdc_186772_DS1.pdf
• File Type:
  [PDF - 217.25 KB ]