Modulation of Tumor Development by Butylated Hydroxytoluene in Experimental Animals

Details

• Personal Author:
  Witschi H
• Description:
  The available data on the tumor-modulating effects of BHT in a variety of tissues and organs of rats and mice are analyzed. Examples were found for both tumor enhancement by BIIT and for an inhibitory action of the antioxidant on tumor formation. A total of 33 papers describing such an effect were examined. Selection was limited to papers where BHT was administered to experimental animals in the diet; all other routes of exposure were excluded. Accordingly, the bulk of available data on tumor promotion in mouse lung by BHT was ignored in the present analysis, although this particular system offers the most insight into possible mechanisms (Malkinson, 1989; Witschi et al., 1989). [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Chemistry Digestive System Digestive System Diseases Laboratories Liver Neoplasms Occupational Health Safety
• Keywords:
  Animal-studies Carcinogenicity Carcinomas Chemical-indicators Chemical-properties Chemical-synthesis Dose-response Hepatocytes Hepatotoxicity Hepatotoxins Laboratory-animals Liver-cancer Liver-damage Liver-disorders

  More +
• ISSN:
  0748-2337
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  259-281
• Volume:
  9
• Issue:
  1
• NIOSHTIC Number:
  nn:20032753
• Citation:
  Toxicol Ind Health 1993 Jan-Apr; 9(1-2):259-281
• Contact Point Address:
  Hanspeter Witschi: ITEH, University of CA, Davis, CA 95616
• CAS Registry Number:
  2,6-Di-tert-butyl-4-methylphenol (CAS RN 128-37-0)
• Federal Fiscal Year:
  1993
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  19900930
• Source Full Name:
  Toxicology and Industrial Health
• End Date:
  20020929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:483200d8003a4bc3fbbe88aad65b7f5c1ca0a54446ac678b8df24ab5a676fee49311eb403bb7357bbebc6ec90962336179e8706606525db566d667e48988fcc6
• Download URL:
  https://stacks.cdc.gov/view/cdc/186607/cdc_186607_DS1.pdf
• File Type:
  [PDF - 1.62 MB ]