Aerobic Exercise as a Countermeasure for Microgravity-Induced Bone Loss and Muscle Atrophy in a Rat Hindlimb Suspension Model

Details

• Personal Author:
  Bradley-Popovich G ; Bryner RW ; Clovis N ; Cutlip, Robert G. ; Norman TL
• Description:
  Background: Loss of bone and skeletal muscle atrophy resulting from non-weight-bearing are major concerns associated with microgravity environment and spaceflight deconditioning. The objective of this research was to address the fundamental issue of whether bone loss and muscle atrophy could be attenuated using weight-bearing aerobic exercise on a treadmill as a countermeasure in rats subjected to simulated weightlessness by hindlimb suspension. Method: Bone and muscle from control and hindlimb-suspended groups with and without exercise were evaluated by bone mineral density (BMD), mechanical tests, bone histomorphometry and muscle mass. Results: Femoral BMD of hindlimb-suspended (HS) rats subjected to treadmill exercise was significantly greater than femoral BMD of HS rats without exercise and also was equivalent to that of weight-bearing controls. Muscle mass from HS rats exercised on a treadmill was significantly greater than muscle mass from HS rats that did not exercise. Exercise did not result in muscle mass equal to that of controls, however. In addition, histomorphometric analysis of the metaphysis of the proximal tibia revealed that HS rats that exercised did not maintain bone formation equivalent to controls. No other bone parameters were found to vary significantly between groups. Conclusions: It was concluded that moderate aerobic exercise on a treadmill did attenuate bone loss and muscle atrophy due to simulated weightlessness by hindlimb suspension, however its effectiveness differed by tissue, anatomical site and parameter investigated. [Description provided by NIOSH]
• Subjects:
  Animals Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  Analytical-methods Analytical-processes Animal-studies Bone-disorders Bone-structure Cell-biology Cell-differentiation Cell-function Cell-metabolism Cellular-transport-mechanism Musculoskeletal-system Musculoskeletal-system-disorders Physical-exercise Physiological-function Physiological-response Physiological-stress Physiology Skeletal-defects Skeletal-disorders Skeletal-stress Skeletal-system Skeletal-system-disorders

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• ISSN:
  0095-6562
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  71
• Issue:
  6
• NIOSHTIC Number:
  nn:20032671
• Citation:
  Aviat Space Environ Med 2000 Jun; 71(6):593-598
• Contact Point Address:
  Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown 26506-9196
• Email:
  tnorman@wvu.edu
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  Aviation, Space, and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f071297fc41344a17a66a51e695882f0d13c74e308016164291c264c5787e55f6b5035ff2d1b6fa820778bf00c9e1911b029cb19b49a28062198b03863efe5e7
• Download URL:
  https://stacks.cdc.gov/view/cdc/186561/cdc_186561_DS1.pdf
• File Type:
  [PDF - 1.69 MB ]