Changes in Force by Repeated Stretches of Skeletal Muscle in Young and Old Female Sprague Dawley Rats

Details

• Personal Author:
  Stauber WT ; Williams ME
• Description:
  We examined whether the decline in isometric force and peak stretch force during repeated stretches of activated plantar flexor muscles was larger in old (24 months, N=5) compared with young (4 months, N=5) female Sprague Dawley rats. Thirty stretches were imposed on isometric contractions (stimulation time 1.9 s, rest periods 180 s) by ankle rotation from 90 degrees to 40 degrees at 50 degrees x s(-1). Even though muscle weights were similar 2094 +/- 54 (young) vs 2033 +/- 73 mg (old) (mean +/- SE), the isometric force (IF) at 90 degrees before stretch 1 and peak stretch force (PSF) at 40 degrees for stretch 1 were lower in old rats 18.9 +/- 0.5 vs 15.5 +/- 1.4 N (p=0.024) and 25.8 +/- 1.3 vs 20.5 +/- 0.9 N (p=0.017). After the stretches, the IF deficit was similar 38.5 +/- 3.0% (young) vs 39.8 +/- 3.4% (old) and did not recover after 1 hour of rest 35.1+/- 4.1% (young) vs 36.9 +/- 4.3% (old). The decline in PSF was/also similar 36.0 +/- 5.2% (young) vs 26.6 +/- 1.8% (old). Skeletal muscles of 24-month-old female Sprague Dawley rats were weaker than 4-month-old rats but had similar susceptibility to develop IF deficits after stretches of activated muscles. Description provided by NIOSH
• Subjects:
  • Animals
  • Laboratories
  • Musculoskeletal Diseases
  • Musculoskeletal System
  • Occupational Health
  • Safety
• Keywords:
  • Laboratory animals
  • Animals
  • Animal studies
  • Muscles
  • Musculoskeletal system disorders
  • Skeletal system disorders
  • Skeletal disorders
• ISSN:
  0394-9532
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  478-481
• Volume:
  12
• Issue:
  6
• NIOSHTIC Number:
  nn:20029515
• Citation:
  Aging 2000 Dec; 12(6):478-481
• Contact Point Address:
  Department of Biochemistry, P.O. Box 9142, West Virginia University Health Sciences Center, Morgantown, WV 26506-9142
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  West Virginia University, Morgantown, West Virginia
• Peer Reviewed:
  True
• Start Date:
  19920101
• Source Full Name:
  Aging: Clinical and Experimental Research
• End Date:
  20050531
• Download URL:
  https://stacks.cdc.gov/view/cdc/190471/cdc_190471_DS1.pdf
• File Type:
  [PDF - 499.34 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e67067b2a34880a3a744528f10470960bdb2d79993327411a76ad541ba413d4e29a058cb55093233fc5c7403d2180b3a2bdb6bcfa17ace2cd16105f71d634bef