Global Patterns of Gene Expression Following Inhalation of Toluene Diisocyanate Suggest Development of Allergic Rhinitis

Details

• Personal Author:
  Johnson VJ ; Kashon ML ; Luster MI ; Yucesoy, Berran
• Description:
  Rhinitis is often a comorbid and preceding disease in workers afflicted with toluene diisocyanate (TDI) asthma. We hypothesized that TDI rhinitis is driven by an allergic immune response rather than innate inflammation. Global patterns of gene expression were examined via microarray in a murine model of TDI rhinitis and compared to acute nasal exposure to lipopolysaccharide (LPS). Histological analysis showed extensive inflammation of the nasal mucosa with eosinophils and neutrophils dominating in the TDI and LPS models, respectively. Effector cell recruitment correlated with expression of chemokines directed towards eosinophils in TDI rhinitis and neutrophils in LPS rhinitis. Genes involved in antigen processing/presentation, lymphocyte activation/regulation, cytokine-receptor signaling and humoral immunity were differentially regulated in TDI rhinitis. In contrast, inflammatory, innate immune and defense responses as well as response to pathogens/biotics were over represented in LPS rhinitis. These results indicate that exposure to TDI results in an antigen-driven immune response in the nasal mucosa suggestive of allergic rhinitis. [Description provided by NIOSH]
• Subjects:
  Antibodies Asthma Asthma, Occupational Genetics Nose Occupational Health Respiratory Tract Diseases Safety Sense Organs
• Keywords:
  Antibody-response Biodynamics Bronchial-asthma Genes Genetic-factors Models Nasal-disorders Pulmonary-system-disorders Respiratory-system-disorders
• ISSN:
  0022-1767
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  178
• Issue:
  1
• NIOSHTIC Number:
  nn:20032578
• Citation:
  J Immunol 2007 Apr; 178(1)(Suppl):S19
• Contact Point Address:
  Dr. Victor J. Johnson, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mail Stop 3014, Morgantown, WV 26505-2888
• Email:
  vjohnson3@cdc.gov
• CAS Registry Number:
  Toluene 2,4-diisocyanate (CAS RN 584-84-9)
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Peer Reviewed:
  True
• Source Full Name:
  The Journal of Immunology
• Supplement:
  Suppl
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2e1ddd036a611a1ffbde72fbc15ac2b4ad507fd164134bdaeda45304786ae388f44d7df25bd7a9784af4ae81c17f8fb1133a96f3a483022e333c638af15d3632
• Download URL:
  https://stacks.cdc.gov/view/cdc/186497/cdc_186497_DS1.pdf
• File Type:
  [PDF - 157.04 KB ]