Association of Genetic Variations in Inflammatory and Fibrogenic Genes with Progressive Massive Fibrosis in Coal Miners

Details

• Personal Author:
  Fluharty K ; Germolec D ; Johnson VJ ; Kashon ML ; Kissling G ; Luster MI ; Slaven, James E. ; Vallyathan V ; Yucesoy, Berran
• Description:
  Progressive massive fibrosis (PMF) is a chronic interstitial lung disease with a complex etiology. Cytokines, growth factors and cell-surface adhesion molecules play crucial roles in the pathogenesis of pulmonary fibrosis by mediating inflammation, fibroblast proliferation, angiogenesis and collagen synthesis. We examined the influence of functional single nucleotide polymorphisms (SNP) in interleukin-1 and 6, tumor necrosis factor-, transforming growth factor-, vascular endothelial growth factor, epithelial growth factor and intercellular adhesion molecule-1 genes on the development of PMF. A total of 648 ex-coal miners from the National Coal Workers Autopsy Study were examined in a case-control study. Genotype analysis was performed on genomic DNA using 5' nuclease PCR assay. There were no significant differences in the frequencies of individual SNPs between PMF and control groups. However, gene-gene interactions were found between TNF alpha308/-238, VEGF+405 / ICAM-1+241 and VEGF+405 / ICAM-1+241 / IL-6+174 (p<0.05) variants. These data suggest that genetic variant of cytokine and fibrogenic genes may play role in individual susceptibility to PMF initiated presumably by coal dust. [Description provided by NIOSH]
• Subjects:
  Antibodies Asthma Asthma, Occupational Coal Coal Mining Dust Genetics Irritants Mining Occupational Health Respiratory Tract Diseases Safety

  More +
• Keywords:
  Antibody-response Biodynamics Bronchial-asthma Cell-function Cell-metabolism Coal-miners Coal-mining Coal-workers Dust-analysis Dust-exposure Dust-inhalation Genes Genetic-factors Models Pulmonary-system-disorders Respiratory-irritants Respiratory-system-disorders

  More +
• ISSN:
  0022-1767
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  178
• Issue:
  1
• NIOSHTIC Number:
  nn:20032580
• Citation:
  J Immunol 2007 Apr; 178(1)(Suppl):S11
• Contact Point Address:
  Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mail Stop 3014, Morgantown, WV 26505-2888
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Peer Reviewed:
  True
• Source Full Name:
  The Journal of Immunology
• Supplement:
  Suppl
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5ab8bc48f001a6b9394223845a50f4036d68d8944bb82b51e0d0aa4a73fc7580917b4043dad3f5c28f2a95b17c12c8307f33c0c169d0198c3dd21aaf9c0f8c9b
• Download URL:
  https://stacks.cdc.gov/view/cdc/186499/cdc_186499_DS1.pdf
• File Type:
  [PDF - 266.31 KB ]