Decline in Lung Function and Mortality: Implications for Medical Monitoring

Details

• Personal Author:
  Attfield, Michael ; Hnizdo, Eva ; Petsonk E ; Sircar K
• Description:
  Aim: To investigate the risk of death associated with selected cut-off points for rate of decline of forced expiratory volume in one second (FEVj). Methods: Mortality rates of a cohort of 1730 coal miners who had performed two pulmonary function tests 12.8 years apart were followed up for an additional 12 years. Based on previous studies, cut-off points for FEVI rate of decline (ml/year) were selected as 30, 60 and 90 ml/year. Cox proportional hazard regression was used to estimate multivariate risk ratio of death n each category. Results: The risk ratios (compared to "below 30 ml/year") were 1.39 (95% Cl 0.99 to 1.97) in the "60 to less " than 90 ml/year category and 1.90 (95% Cl 1.32 to 2.76) in the "90 ml/year and above" category. Rates of decline above 90 ml/year were consistently related to excess mortality. In non-smokers and those with neither restrictive nor obstructive patterns at the first survey, rates of decline above 60 ml/year were significantly associated with increased mortality. Conclusions: Risk of death increases in individuals with rates of decline above about 60 ml/year and is statistically significant with declines of 90 ml/year or more. These results should be useful to healthcare providers in assessing lung function declines observed in individuals. [Description provided by NIOSH]
• Subjects:
  Coal Coal Mining Lung Lung Diseases Mining Mortality Occupational Health Respiratory Function Tests Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Coal-miners Lung-disorders Lung-function Mortality-data Mortality-rates Pulmonary-function Pulmonary-function-tests Pulmonary-system-disorders Respiratory-system-disorders Statistical-analysis Surveillance

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• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  461-466
• Volume:
  64
• Issue:
  7
• NIOSHTIC Number:
  nn:20032501
• Citation:
  Occup Environ Med 2007 Jul; 64(7):461-466
• Contact Point Address:
  Dr K Sircar National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  KSircar@cdc.gov
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  All Sectors
• Peer Reviewed:
  True
• Source Full Name:
  Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4a99c3bdba6e53bef63d470eb9f6036ec472c324372a20590e0d75cb33d6d89cebe570086d0ea7b8fd4d96cbdca637c3c81e0d030c62fc5a47e4c3e74e51b6b0
• Download URL:
  https://stacks.cdc.gov/view/cdc/186443/cdc_186443_DS1.pdf
• File Type:
  [PDF - 157.12 KB ]