When Is FEV1 Loss Excessive? – An Investigation of the Relationship Between Year-to-Year and Long-Term Spirometry Changes

Details

• Personal Author:
  Avashia B ; Petsonk, Edward L. ; Wang, Mei Lin
• Description:
  Spirometry is performed to monitor lung health, but variability between tests can hinder recognition of excessive FEV1 declines. We explored the relationship between year-to-year and long-term (average 18 yrs) FEV1 slopes, using 21,821 results from 1,884 workers who participated in annual spirometry at a chemical plant between 1973 and 2003. Workers with >/=5 valid results over >/= 10 years were included (initial age: mean 35, range 18-62 yrs; 91% male; 35% current smokers, 41% nonsmokers). Long-term FEV1 slopes (ml/yr) were calculated for each worker by simple linear regression using all available results, and compared to year-to-year differences (deltaFEV1) in both % and milliliters. Long-term slopes averaged -29.1 ml/yr (-27, -29, -37 ml/yr for male, and -20, -26, and -27 ml/yr for female non-, ex- and cur- smokers, respectively). Excessive long-term decline was defined by the lower 5th%ile of all individual slopes, -68.0 ml/yr. When interpreting yearly FEV1 change using the 5th%ile of deltaFEV1 (-10% or -360 ml) as normal limits, individuals with abnormal short-term declines are more likely to ultimately show excessive long-term declines (odds ratio=3.8). [Description provided by NIOSH]
• Subjects:
  Epidemiology Lung Lung Diseases Mortality Occupational Health Respiratory Function Tests Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Lung-function Mortality-data Mortality-rates Mortality-surveys Pulmonary-disorders Pulmonary-function Pulmonary-function-tests Pulmonary-system-disorders Respiratory-system-disorders Spirometry Statistical-analysis Surveillance

  More +
• ISSN:
  0903-1936
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  24
• NIOSHTIC Number:
  nn:20026034
• Citation:
  Eur Respir J 2004 Sep; 24(48):434S
• Contact Point Address:
  Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  False
• Source Full Name:
  European Respiratory Journal. 14th ERS Annual Congress, Glasgow, UK, September 4-8, 2004
• Supplement:
  48
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0c8e48a581ee4f9e5b52150f36b8f942514f412d63c946b1037c77caf892ef696da75170ad4484da7e7531bd25212bf49ef445cbdccc25fa81c1f4f5c8f41d68
• Download URL:
  https://stacks.cdc.gov/view/cdc/197159/cdc_197159_DS1.pdf
• File Type:
  [PDF - 304.90 KB ]