Pulmonary Effects of Single-Walled Carbon Nanotubes: Inflammatory Response, Oxidative Stress/Signaling, and Recognition by Macrophages

Details

• Personal Author:
  Castranova, Vincent ; Kagan VE ; Kisin ER ; Meighan T ; Murray AR ; Rao KMK ; Shvedova AA ; Tyurina YY ; Young SH
• Description:
  Nanosized materiaols and nano-scaled processes are believed to be beneficial for many industries as well as for medicine. However, irrational unjustified use of nanomaterials may also pose risks to human health and the environment, particularly single-walled carbon nanotubes, such as their decytotoxid effects, their ability to cause an inflammatory response, and induction of oxidative stress. Further, recognigion and engulfment of nanotubes in tissue and circulation are discussed. Possible involvement of lung fibroblast pulmonary responses to nanotubes are considered. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Occupational Health Particulate Matter Safety Toxicology
• Keywords:
  Aerosol-particles Airborne-fibers Airborne-particles Author Keywords: Occupational Exposure Free Radicals Lung Fibrosis Metals Nanotechnology Neutrophils Transition
• ISBN:
  9781402060755
• Publisher:
  Springer
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  65-75
• NIOSHTIC Number:
  nn:20032331
• Citation:
  Nanotechnology - toxicological issues and environmental safety (NATO science for peace and security series / NATO science for peace and security series C: environmental security). Simeonova PP, Opopol N, Luster MI. eds. Dordrecht, The Netherlands: Springer, 2007 May; :65-75
• Contact Point Address:
  Pathology/Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
• Editor(s):
  Simeonova PP; Opopol N; Luster MI
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Nanotechnology - toxicological issues and environmental safety (NATO science for peace and security series / NATO science for peace and security series C: environmental security)
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f924d8bc5c44c4d05fdb42dda179070a25766aff63b0afdaaba6c7e90424facb1e1c473ff3c15c111c48f3cf0b7ac9eb00aa3d2ddc0d5e63a3be9495c77ef68d
• Download URL:
  https://stacks.cdc.gov/view/cdc/186351/cdc_186351_DS1.pdf
• File Type:
  [PDF - 1.49 MB ]