A Proposed Testing Framework for Developmental Immunotoxicology (DIT)

Details

• Personal Author:
  Burns-Naas LA ; Hastings KL ; Holsapple MP ; Ladics GS ; Lavin AL ; Luster MI ; Makris SL ; Yang Y ; Burns-Naas LA ; Hastings KL ; Holsapple MP ; Ladics GS ; Lavin AL ; Luster MI ; Makris SL ; Yang Y
• Description:
  A group of thirty immunotoxicology experts from the U.S. and E.U. representing government, industry, and academia met in May 2003, in Washington, D.C., to reach consensus regarding the most appropriate methods to assess developmental immunotoxicology (DIT) for hazard identification, including under what conditions such testing might be required. The following points represent the major conclusions from this roundtable discussion: (1) the rat is the preferred model; (2) any DIT protocol should be based on immune assays already validated; (3) DIT methods should be incorporated into standard developmental and reproductive toxicity protocols to the extent possible rather than a "stand-alone" protocol; (4) the approach to address DIT potential should be similar for chemicals and drugs, but the experimental design should be flexible and should reflect the specific questions to be answered; (5) it is possible to utilize a study design that assesses all critical windows in one protocol, with the results leading to further study of specific effects, as warranted; (6) animals should be exposed throughout the treatment protocol; (7) the triggers for DIT may include structure-activity-relationships, results from other toxicity studies, the intended use of a drug/chemical and/or its anticipated exposure of neonates and/or juveniles. [Description provided by NIOSH]
• Subjects:
  Age Factors Animals Chemistry Hazardous Substances Hypersensitivity Immune System Occupational Health Safety Surveys And Questionnaires Urogenital Diseases Urogenital System

  More +
• Keywords:
  Age-factors Animal-studies Chemical-hypersensitivity Chemical-properties Chemical-reactions Immunochemistry Immunologic-disorders Quantitative-analysis Questionnaires Reproductive-hazards Toxic-effects Toxins

  More +
• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  California ; Delaware ; District of Columbia ; Maryland ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  18-24
• Volume:
  83
• Issue:
  1
• NIOSHTIC Number:
  nn:20032291
• Citation:
  Toxicol Sci 2005 Jan; 83(1):18-24
• Email:
  mholsapple@ilsi.org
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  True
• Source Full Name:
  Toxicological Sciences
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f501ba96a2c6f09e9494830e3b50fb5109747ec8b060c1da29f5803ab985212073850e237879d54415367bcfd00a5f1b1561e1785c6e6a29efaf17633d0811f1
• Download URL:
  https://stacks.cdc.gov/view/cdc/186318/cdc_186318_DS1.pdf
• File Type:
  [PDF - 226.06 KB ]