Antigenic Diversity of Enteroviruses Associated with Nonpolio Acute Flaccid Paralysis, India, 2007–2009

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Rao, C. Durga ; Yergolkar, Prasanna ; Shankarappa, K. Subbanna
• Description:
  Because of the broadened acute flacid paralysis (AFP) definition and enhanced surveillance, many nonpolio AFP (NP-AFP) cases have been reported in India since 2005. To determine the spectrum of nonpolio enterovirus (NPEV) serotypes associated with NP-AFP from polio-endemic and -free regions, we studied antigenic diversity of AFP-associated NPEVs. Of fecal specimens from 2,786 children with NP-AFP in 1 polio-endemic and 2 polio-free states, 823 (29.5%) were positive for NPEVs in RD cells, of which 532 (64.6%) were positive by viral protein 1 reverse transcription PCR. We identified 66 serotypes among 581 isolates, with enterovirus 71 most frequently (8.43%) detected, followed by enterovirus 13 (7.1%) and coxsackievirus B5 (5.0%). Most strains within a serotype represented new genogropups or subgenogroups. Agents for ≈35.0% and 70.0% of culture-positive and -negative cases, respectively, need to be identified. Association of human enterovirus with NP-AFP requires better assessment and understanding of health risks of NPEV infections after polio elimination.
• Subjects:
  • Research
  • Acute Disease
  • Antigenic Variation
  • Child, Preschool
  • Enterovirus
  • Enterovirus Infections
  • Humans
  • Incidence
  • Infant
  • Molecular Sequence Data
  More +
• Source:
  Emerg Infect Dis. 18(11):1833-1840.
• Document Type:
  Journal Article
• Place as Subject:
  India
• Location:
  Asia
• Volume:
  18
• Issue:
  11
• Download URL:
  https://stacks.cdc.gov/view/cdc/18631/cdc_18631_DS1.pdf
• File Type:
  [PDF - 503.30 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:72fc3f83a71ca02c28ed09224c803b354e98a7f224ef5f8bf4c0eb5fb4ae543c