The Effect of the 14-Day Agricultural Restricted Entry Interval on Azinphosmethyl Exposures in a Group of Apple Thinners in Washington State

Details

• Personal Author:
  Curl CL ; Fenske RA ; Kissel JC
• Description:
  We examined the effect of the 14-day agricultural restricted entry period on absorbed pesticide doses in a group of twenty experienced apple thinners. Thinners entered orchards 1-49 days following azinphosmethyl applications. Urine samples (n=296) collected throughout the thinning season were analyzed for the three dialkylphosphate metabolites of azinphosmethyl to estimate absorbed daily doses. Separate dose distributions were created for samples collected when the interval was <14 days, or 14 days or more; geometric mean doses for these two categories differed by a factor of two (42 and 19 ug/kg/day, respectively; p<0.0001). Dose estimates were compared to US Environmental Protection Agency and California EPA regulatory guidance values for occupational azinphosmethyl risk. None of the doses exceeded the U.S. EPA NOAEL (560 µg/kg/day), but nearly all had a margin of exposure of less than 100. Addition of a 10-fold uncertainty factor to California EPAs NOAEL produced a guidance value of 75 µg/kg/day. Only 2.4% of the doses exceeded this value for re-entry intervals 14 days or more, while 27% exceeded the value for re-entry intervals <14 days. We conclude that the 14-day restricted entry interval provides an appropriate level of worker health protection under the field conditions studied. [Description provided by NIOSH]
• Subjects:
  Agriculture Hazardous Substances Insecticides Occupational Exposure Occupational Health Safety Urine
• Keywords:
  Absorption-rates Agricultural-chemicals Exposure-levels Health-hazards Occupational-exposure Occupational-hazards Occupational-health Pesticides Urinalysis
• ISSN:
  0273-2300
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  91-97
• Volume:
  38
• Issue:
  1
• NIOSHTIC Number:
  nn:20032251
• Citation:
  Regul Toxicol Pharmacol 2003 Aug; 38(1):91-97
• Contact Point Address:
  Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195-7234
• Email:
  rfenske@u.washington.edu
• CAS Registry Number:
  Azinphos-methyl (CAS RN 86-50-0)
• Federal Fiscal Year:
  2003
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Regulatory Toxicology and Pharmacology
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0b881636cff4df0735669d316a88bfcd47144748015b5c247e84ea69198b6b5e3bfc1339071a99b1212a24fc4cee42a55eb02ad0189000941995b527a3b5b771
• Download URL:
  https://stacks.cdc.gov/view/cdc/186282/cdc_186282_DS1.pdf
• File Type:
  [PDF - 185.62 KB ]