Exposure to the Immunosuppresant, Perfluorooctanoic Acid, Enhances the Murine IgE and Airway Hyperreactivity Response to Ovalbumin

Details

• Personal Author:
  Anderson, Stacey E. ; Fairley KJ ; Kearns S ; Meade BJ ; Purdy R
• Description:
  These studies were conducted to investigate the role of dermal exposure to perfluorooctanoic acid (PFOA), a known immunosuppressant, on the hypersensitivity response to ovalbumin (OVA) in a murine model of asthma. PFOA has had widespread use as a carpet and fabric protectant. BALB/c mice were exposed dermally, on the dorsal surface of each ear, to concentrations of PFOA ranging from 0.01 to 1.5% (applied dose 0.25-50 mg/kg) for 4 days. In hypersensitivity studies, mice were also ip injected with 7.5 µg OVA and 2 mg alum on days 1 and 10 and in some studies challenged with 250 µg OVA by pharyngeal aspiration on days 17 and 26. Following exposure to PFOA, an increase in liver weights and a decrease in thymus and spleen weights and cellularities were observed. Similar immunomodulatory trends were demonstrated in mice coadministered PFOA and OVA. Compared to the OVA alone-exposed animals, an increase in total IgE was demonstrated when mice were coexposed to OVA and concentrations of PFOA ranging from 0.75 to 1.5%, while the OVA-specific IgE response peaked with 0.75% PFOA coexposure (p less than or equal to 0.05). OVA-specific airway hyperreactivity was increased in the 1.0% PFOA coexposed group (p less than or equal to 0.05), with an increased pleiotropic cell response characterized by eosinophilia and mucin production, in animals coexposed to concentrations of PFOA up to 1.0%, as compared to the OVA alone-exposed animals. In a murine model, PFOA was demonstrated to be immunotoxic following dermal exposure, with an enhancement of the hypersensitivity response to OVA, suggesting that PFOA exposure may augment the IgE response to environmental allergens. [Description provided by NIOSH]
• Subjects:
  Acids Animals Hazardous Substances Hypersensitivity Immune System Laboratories Occupational Health Safety
• Keywords:
  Allergens Allergic-reactions Animal-studies Cellular-reactions Dose-response Exposure-levels Immune-reaction Immune-system Immunotoxins Laboratory-animals Models Toxic-effects

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; OSHA Region 5 ; West Virginia ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OD - Office of the Director
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  375-383
• Volume:
  97
• Issue:
  2
• NIOSHTIC Number:
  nn:20032107
• Citation:
  Toxicol Sci 2007 Jun; 97(2):375-383
• Contact Point Address:
  National Institute for Occupational Safety and Health, MS 4020, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  bhm8@cdc.gov
• CAS Registry Number:
  Perfluorooctanoic acid (CAS RN 335-67-1)
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Peer Reviewed:
  True
• Source Full Name:
  Toxicological Sciences
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c4850fc2d621ef18f2e95f9e78a93d5e007ee9b09aa88058fb3ca6dc60efcfa48aa2f24f32e26c1ad1ccdc0641a4007b890b022baab7879983e4cceda196ca89
• Download URL:
  https://stacks.cdc.gov/view/cdc/186159/cdc_186159_DS1.pdf
• File Type:
  [PDF - 574.64 KB ]