The Importance of Cytochrome P450 2B6 in the Human Metabolism of Environmental Chemicals

Details

• Personal Author:
  Hodgson E ; Rose RL
• Description:
  Cytochrome P450 (CYP) 2B6 (CYP2B6) is a human CYP isoform found in variable amounts in the liver and other organs. It is known to be inducible and polymorphic and has a wide range of xenobiotic substrates. Studies of CYP2B6 to date have concentrated heavily on clinical drugs. In the present communication, however, we concentrate on its role in the metabolism of environmental xenobiotics. The term environment is used, in its broadest sense, to include natural ecosystems and agroecosystems as well as the industrial and indoor domestic environments. In essence, this excludes only clinical drugs and drugs of abuse. Many of these chemicals, including agrochemicals and industrial chemicals, can serve as substrates, inhibitors and/or inducers of CYP2B6, these activities being often modified by the existence of polymorphic variants. Metabolism-based interactions between environmental chemicals are discussed, as well as the emerging possibility of metabolic interactions between environmental chemicals and clinical drugs. [Description provided by NIOSH]
• Subjects:
  Agriculture Chemistry Clinical Laboratory Techniques Ecology Energy Metabolism Environmental Exposure Insecticides Occupational Health Safety Urogenital System Workplace

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• Keywords:
  Agricultural-chemicals Agricultural-industry Author Keywords: Agrochemicals Chemical-properties Clinical-chemistry Cytochrome P450 Cytochrome P450 2B6 Ecological-systems Environmental-exposure Environmental Chemicals Fertility Humans Induction Industrial Chemicals Inhibition Metabolic-disorders Metabolic-rate Metabolic-study Metabolism Pesticides-and-agricultural-chemicals Polymorphisms Work-environment Xenobiotics

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• ISSN:
  0163-7258
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; North Carolina ; OSHA Region 3 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  420-428
• Volume:
  113
• Issue:
  2
• NIOSHTIC Number:
  nn:20032039
• Citation:
  Pharmacol Ther 2007 Feb; 113(2):420-428
• Contact Point Address:
  Department of Environmental and Molecular Toxicology, North Carolina State University, PO Box 7633, Raleigh, NC 27695
• Email:
  ernest_hodgson@ncsu.edu
• CAS Registry Number:
  Carbofuran (CAS RN 1563-66-2)
• Federal Fiscal Year:
  2007
• Performing Organization:
  East Carolina University
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Pharmacology & Therapeutics
• End Date:
  20080929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:aeeff917af0f7fdb70284667c14fe787188e2e98a4646cc62496f716d2e4b73e5f7ead6be078d777e7c83d7b1c29af432a90d302033ffb48dd30299d2f767137
• Download URL:
  https://stacks.cdc.gov/view/cdc/186125/cdc_186125_DS1.pdf
• File Type:
  [PDF - 198.44 KB ]