TNF-Alpha Polymorphisms in Chronic Beryllium Disease and Beryllium Sensitization

Details

• Personal Author:
  Ensey JS ; Frye BL ; Kreiss, Kathleen ; McCanlies EC ; Schuler, Christine R. ; Weston A
• Description:
  Objective: Tumor necrosis factor-alpha (TNF-alpha) is a potent cytokine involved in normal immune functions. The aim of this study was to investigate if there is an association between chronic beryllium disease or beryllium sensitization and two variants of the TAT-a gene located at -308 and -238 called TNF-alpha-308*02 and TNF-alpha-238*02. Methods: TNF-alpha-308 and TNF-alpha-238 genotyping was conducted in a large, population-based cohort consisting of 886 beryllium workers (92 individuals with chronic beryllium disease, 64 who were beryllium sensitized, and 730 individuals without sensitization or disease). Results: The odds of chronic beryllium disease in the presence of at least one TNF-alpha-308*02 or TNF-alpha-238*02 allele was not significant (OR 1.0, 95% CI = 0.7, 1.7 and OR = 0.8; 95% CI = 0.4, 1.6). This was true regardless of whether a worker was homozygous or heterozygous for TNF-alpha-308*02 or TNF-alpha-238*02. Similarly, neither allele was associated with sensitization (P > 0.05). Conclusions: Unlike an earlier report, there was no association between these specific TNF-alpha alleles and either chronic beryllium disease or sensitization to beryllium. [Description provided by NIOSH]
• Subjects:
  Genetics Hypersensitivity Immune System Occupational Health Safety Workplace
• Keywords:
  Chemical-hypersensitivity Genetic-factors Immune-reaction Immune-system Immunologic-disorders Sensitization Work-environment
• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  446-452
• Volume:
  49
• Issue:
  4
• NIOSHTIC Number:
  nn:20032035
• Citation:
  J Occup Environ Med 2007 Apr; 49(4):446-452
• Contact Point Address:
  Erin C. McCanlies, PhD, CDC, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS-L4050, Morgantown WV 26505
• Email:
  EIM4@CDC.GOV
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a94455f851c2550ed7c9ed174554f79c0568d22709c5162667b2c7ee5a50424962842c2562e0228bf9ba9c196d2489514f297cdc691bd4e0d6ce8170ebf2e846
• Download URL:
  https://stacks.cdc.gov/view/cdc/186122/cdc_186122_DS1.pdf
• File Type:
  [PDF - 186.36 KB ]