Predicting Cutaneous Permeability of Biocides Using LSER Approach

Details

• Personal Author:
  Barlow BM ; Baynes RE ; Vijay V ; Yeatts JL
• Description:
  The permeation of a chemical through skin is influenced by its physico-chemical characteristics and the biological characteristics of the skin. In predicting dermal absorption, scientists have proposed different mathematical models to correlate physico-chemical (especially solvatochromatic parameters) and biological interactions occurring in the process of permeation. Previous studies have shown that hydrophobicity, polarity, molecular volume and hydrogen bonding capability of chemicals are among the most important characteristics to be used for predicting permeability. The aim of this study is to predict dermal absorption of different biocides (with wide range of Kow) using modified Linear Solvation Energy Relationship (LSER) approach, with a calibrated flow through diffusion system. Infinite doses of biocides belonging to five different classes; phenols, morpholines, oxazolidines, isothiazolines and triazines in aqueous solutions were applied to porcine skin flow through diffusion cells. These perfusates were analyzed by GCMS and HPLC to determine skin permeability. The system coefficients (r, s, a, b, v) of a calibrated set of solutes of the system were determined from multiple linear regression analysis and plugged into the LSER equation to predict permeability values for the several biocides. Our preliminary data with 2 phenols; o-phenylphenol and p-chloro-o-cresol, have shown that the predicted permeability values were very close to observed values, demonstrating that our calibrated system can efficiently predict permeability of biocides. In further studies, the permeability of biocides will be determined in various solvents and commercially available metalworking fluids, so to assess the behavior of biocides in mixtures and to determine the solvatochromatic parameter that has the most prominent effect in predicting permeability. [Description provided by NIOSH]
• Subjects:
  Dermatitis Occupational Health Oxidants Safety Skin Skin Absorption Skin Diseases
• Keywords:
  Cell-alteration Cell-biology Cell-damage Cell-function Cell-metabolism Cellular-reactions Dermatosis Mathematical-models Oxidation Oxidative-metabolism Oxidative-processes Skin-absorption Skin-diseases Skin-disorders Skin-exposure Skin-irritants Skin-sensitivity Statistical-analysis

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• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  96
• Issue:
  1
• NIOSHTIC Number:
  nn:20031938
• Citation:
  Toxicologist 2007 Mar; 96(1):432
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  North Carolina State University, Raleigh, North Carolina
• Peer Reviewed:
  False
• Start Date:
  20000801
• Source Full Name:
  The Toxicologist. Society of Toxicology 46th Annual Meeting and ToxExpo, March 25-29, 2007, Charlotte, North Carolina
• End Date:
  20150731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f7d0455c658e1f1de4828abdfa7895782889fe4c5aa7c39d84dd84d5ca60f59630cb2b6e7466ca16d18f6c9aec853677237e0536da2b7be21c47260579551d2a
• Download URL:
  https://stacks.cdc.gov/view/cdc/186048/cdc_186048_DS1.pdf
• File Type:
  [PDF - 169.39 KB ]