VIM-2–producing Multidrug-Resistant Pseudomonas aeruginosa ST175 Clone, Spain

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Viedma, Esther ; Juan, Carlos ; Villa, Jennifer ; Barrado, Laura ; Orellana, M. Ángeles ; Sanz, Francisca ; Otero, Joaquín R. ; Oliver, Antonio ; Chaves, Fernando
• Description:
  A total of 183 patients were colonized or infected with multidrug-resistant Pseudomonas aeruginosa isolates at a hospital in Spain during 2007-2010; prevalence increased over this period from 2.8% to 15.3%. To characterize these isolates, we performed molecular epidemiologic and drug resistance analysis. Genotyping showed that 104 (56.8%) isolates belonged to a single major clone (clone B), which was identified by multilocus sequence typing as sequence type (ST) 175. This clone was initially isolated from 5 patients in 2008, and then isolated from 23 patients in 2009 and 76 patients in 2010. PCR analysis of clone B isolates identified the bla(VIM-2) gene in all but 1 isolate, which harbored bla(IMP-22). ST175 isolates were susceptible to only amikacin (75%) and colistin (100%). Emergence of the ST175 clone represents a major health problem because it compromises therapy for treatment of P. aeruginosa nosocomial infections.
• Subjects:
  Aged Anti-Bacterial Agents Bacterial Typing Techniques Beta-Lactamases Cross Infection DNA, Bacterial Drug Resistance, Multiple, Bacterial Female Genotype Humans Male Microbial Sensitivity Tests Middle Aged Molecular Epidemiology Multilocus Sequence Typing Prevalence Pseudomonas Infections Sequence Analysis, DNA

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• Source:
  Emerg Infect Dis. 18(8):1235-1241.
• Document Type:
  Journal Article
• Place as Subject:
  Spain
• Volume:
  18
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:03b1f914f4a8de6af6554aac87f86afdd56544ce5667d5df02c301eed58ee233
• Download URL:
  https://stacks.cdc.gov/view/cdc/18603/cdc_18603_DS1.pdf
• File Type:
  [PDF - 237.34 KB ]