VIM-2–producing Multidrug-Resistant Pseudomonas aeruginosa ST175 Clone, Spain
Published Date:Aug 2012
Source:Emerg Infect Dis. 18(8):1235-1241.
Bacterial Typing Techniques
Drug Resistance, Multiple, Bacterial
Microbial Sensitivity Tests
Multilocus Sequence Typing
Sequence Analysis, DNA
Description:A total of 183 patients were colonized or infected with multidrug-resistant Pseudomonas aeruginosa isolates at a hospital in Spain during 2007-2010; prevalence increased over this period from 2.8% to 15.3%. To characterize these isolates, we performed molecular epidemiologic and drug resistance analysis. Genotyping showed that 104 (56.8%) isolates belonged to a single major clone (clone B), which was identified by multilocus sequence typing as sequence type (ST) 175. This clone was initially isolated from 5 patients in 2008, and then isolated from 23 patients in 2009 and 76 patients in 2010. PCR analysis of clone B isolates identified the bla(VIM-2) gene in all but 1 isolate, which harbored bla(IMP-22). ST175 isolates were susceptible to only amikacin (75%) and colistin (100%). Emergence of the ST175 clone represents a major health problem because it compromises therapy for treatment of P. aeruginosa nosocomial infections.
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