Development of a Small Inhalation System for Rodent Exposure to Fine and Ultrafine Titanium Dioxide Aerosols

Details

• Personal Author:
  Castranova, Vincent ; Chen B ; Cumpston J ; Donlin M ; Frazer A ; Frazer D ; Lindsley B ; McKinney W ; Nurkiewicz T ; Schwegler-Berry D ; Stone S ; Vandestouwe, Kurt H.
• Description:
  There has been great attention paid to the potential health effects of fine and ultrafine particles in the working environment. It is not only because of the increased application and use of fine/ultrafine powders in industry, but also due to the concern regarding the association between increased risk of morbidity and mortality and particulate air pollution on PM2,5 and PM(10) (Samet et al. 2000). Although the data imply that PM can affect tissues and organs outside the respiratory tract, as evidenced by the occurrence of cardiovascular dysfunction (Goldberg et al. 2000), the biological mechanisms which evoke systematic effects remain to be defined. In this collaborative research between NIOSH and WVU, we try to understand the mechanisms by identifying significant effects of pulmonary PM exposure on the systemic microcirculation (Nurkiewicz et al. 2004). As an initial step in this effort, a small-scale inhalation system was developed to expose rats to fine/ultrafine TiO2 aerosols. [Description provided by NIOSH]
• Subjects:
  Aerosols Laboratories Occupational Health Particulate Matter Respiratory System Safety
• Keywords:
  Exposure-chambers Inhalation-studies Laboratory-animals Nanotechnology Particulates
• ISBN:
  9780978873509
• Publisher:
  American Association for Aerosol Research
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20031879
• Citation:
  Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota. Biswas P, Chen DR, Hering S, eds. Mount Laurel, NJ: American Association for Aerosol Research, 2006 Sep; :858-859
• Contact Point Address:
  Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
• CAS Registry Number:
  Titania (CAS RN 13463-67-7)
• Editor(s):
  Biswas P; Chen DR; Hering S
• Federal Fiscal Year:
  2006
• Peer Reviewed:
  False
• Source Full Name:
  Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5f69a3fa8845a4c8470a1f62d032e893704030e0f68b94788e0716f803c74007145ad370864eb47bb178eded2e0e8fd149d2417330ca2147810e24d023a81b79
• Download URL:
  https://stacks.cdc.gov/view/cdc/185995/cdc_185995_DS1.pdf
• File Type:
  [PDF - 1.66 MB ]