Cytokine Genotype and Phenotype Effects on Lung Function Decline in Firefighters

Details

• Personal Author:
  Burgess JL ; Fleming J ; Josyula AB ; Kurzius-Spencer M ; Littau SR ; Yucesoy, Berran ; Burgess JL ; Fleming J ; Josyula AB ; Kurzius-Spencer M ; Littau SR ; Yucesoy, Berran
• Description:
  Objective: We conducted this study to evaluate the association of cytokine genotypes and sputum concentrations on longitudinal decline in lung function in firefighters. Methods: In 67 firefighters with at least four pulmonary function tests, DNA was analyzed for functional polymorphisms of interleukin (IL)-1 beta, IL-1 receptor antagonist (IL-1RA), IL-8, IL-10, tumor necrosis factor-alpha (TNF-alpha) genes, and sputum evaluated for cytokine concentration by ELISA. Results: The annual rate of FEV1 decline was greater in firefighters with TT genotypes at IL-10 (-819) (P = 0.009) and with CT or TT genotypes at IL-1RA (2018) (P = 0.050). These genotypes were not associated with concentrations of sputum cytokine, but increased IL-1RA was associated with a slower rate of FEV1 decline (P = 0.025), as was increased sputum macrophage count (P = 0.002). Conclusions: Cytokine genotypes were associated with the rate of FEV1 decline but did not alter concentrations of sputum cytokine. Increased sputum IL-IRA may be protective. [Description provided by NIOSH]
• Subjects:
  Firefighters Fires Genetics Lung Lung Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Fire-fighters Fire-hazards Genes Genetic-factors Lung-disease Lung-disorders Particulate-dust Pulmonary-disorders Pulmonary-function Pulmonary-system-disorders Respiratory-system-disorders

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Arizona ; California ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  282-288
• Volume:
  49
• Issue:
  3
• NIOSHTIC Number:
  nn:20031870
• Citation:
  J Occup Environ Med 2007 Mar; 49(3):282-288
• Contact Point Address:
  Jefferey L. Burgess, MD, MS, MPH, Division of Community, Environment and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona,1295 Martin Ave., Tucson, AZ 85724-5210
• Email:
  jburgess@u.arizona.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6e7f2b965a3b66956938b26febb42a129d5f6d7a96df7e6432e2cbd957f47221093d60ad77bffb686714818b8ae89929f438989d756ff4d3d2e214dba23821fb
• Download URL:
  https://stacks.cdc.gov/view/cdc/185991/cdc_185991_DS1.pdf
• File Type:
  [PDF - 217.91 KB ]