A Theoretical Framework for Evaluating Analytical Digestion Methods for Poorly Soluble Particulate Beryllium

Details

• Personal Author:
  Brink CA ; Brisson MJ ; Day, Gregory A. ; Dickerson RM ; Hoover, Mark D. ; Scripsick RC ; Stefaniak, Aleksandr B. ; Brink CA ; Brisson MJ ; Day, Gregory A. ; Dickerson RM ; Hoover, Mark D. ; Scripsick RC ; Stefaniak, Aleksandr B.
• Description:
  Complete digestion of all chemical forms and sizes of particulate analytes in environmental samples is usually necessary to obtain accurate results with atomic spectroscopy. In the current study, we investigate the physicochemical properties of beryllium particles likely to be encountered in samples collected from different occupational environments and present a hypothesis that a dissolution theory can be used as a conceptual framework to guide development of strategies for digestion procedures. For monodisperse single-chemical constituent primary particles, such as those encountered when handling some types of beryllium oxide (BeO) powder, theory predicts that a digestion procedure is sufficient when it completely dissolves all primary particles, independent of cluster size. For polydisperse single-chemical constituent particles, such as those encountered during the handling of some types of beryllium metal powder, theory predicts that a digestion procedure is sufficient only when it completely dissolves the largest particle in the sample. For samples with unknown or multi-chemical constituent particles and with particles having undefined sizes, e.g., fume emissions from a copper-beryllium alloy furnace operation or dust from a beryl ore crushing operation, a surface area-limited and single-constituent-dependent dissolution theory may not predict complete dissolution, thereby requiring non-routine robust treatment procedures with post-digestion filtration, followed by examination of residual particulate material. Additionally, for beryllium, and likely other poorly soluble materials, particulate reference materials of various chemical forms and size distributions are needed to better evaluate and harmonize analytical digestion procedures. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Biochemistry Chemistry Occupational Health Particulate Matter Safety Workplace
• Keywords:
  Author Keywords: Analytical Methods Beryllium Compounds Biochemical-analysis Biochemical-indicators Chemical-kinetics Chemical-properties Chemical-synthesis Fumes Particle-counters Particulate-sampling-methods Particulates Physiological-chemistry Physiological-measurements Physiological-testing Quantative Analysis Work-analysis Work-areas Work-environment Work-performance

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• ISSN:
  1618-2642
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  New Mexico ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 6 ; South Carolina ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  87
• Issue:
  7
• NIOSHTIC Number:
  nn:20031816
• Citation:
  Anal Bioanal Chem 2007 Apr; 87(7):2411-2417
• Contact Point Address:
  AB Stefaniak, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  AStefaniak@cdc.gov
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7) ; Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  True
• Source Full Name:
  Analytical and Bioanalytical Chemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:afe49d51eb0677de379ce5545b875feed50eedce5104677c4bfcb90a5abf1300df551550b117ec076371bee380ad7465b590cc57060c3c9c0acb3d9c4ea65a21
• Download URL:
  https://stacks.cdc.gov/view/cdc/185964/cdc_185964_DS1.pdf
• File Type:
  [PDF - 180.78 KB ]