Seroprevalence of Antibodies against Chikungunya, Dengue, and Rift Valley Fever Viruses after Febrile Illness Outbreak, Madagascar

Schwarz, Norbert G.; Girmann, Mirko; Randriamampionona, Njary; Bialonski, Alexandra; Maus, Deborah; Krefis, Anne Caroline; Njarasoa, Christine; Rajanalison, Jeanne Fleury; Ramandrisoa, Herly Daniel; Randriarison, Maurice Lucien; May, Jürgen; Schmidt-Chanasit, Jonas; Rakotozandrindrainy, Raphael

i

Seroprevalence of Antibodies against Chikungunya, Dengue, and Rift Valley Fever Viruses after Febrile Illness Outbreak, Madagascar

Supporting Files Public Domain

Nov 2012
By Schwarz, Norbert G. ; Girmann, Mirko ; Randriamampionona, Njary ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Schwarz, Norbert G. ; Girmann, Mirko ; Randriamampionona, Njary ; Bialonski, Alexandra ; Maus, Deborah ; Krefis, Anne Caroline ; Njarasoa, Christine ; Rajanalison, Jeanne Fleury ; Ramandrisoa, Herly Daniel ; Randriarison, Maurice Lucien ; May, Jürgen ; Schmidt-Chanasit, Jonas ; Rakotozandrindrainy, Raphael
Description:

In October 2009, two-3 months after an outbreak of a febrile disease with joint pain on the eastern coast of Madagascar, we assessed serologic markers for chikungunya virus (CHIKV), dengue virus (DENV), and Rift Valley fever virus (RVFV) in 1,244 pregnant women at 6 locations. In 2 eastern coast towns, IgG seroprevalence against CHIKV was 45% and 23%; IgM seroprevalence was 28% and 5%. IgG seroprevalence against DENV was 17% and 11%. No anti-DENV IgM was detected. At 4 locations, 450-1,300 m high, IgG seroprevalence against CHIKV was 0%-3%, suggesting CHIKV had not spread to higher inland-altitudes. Four women had IgG against RVFV, probably antibodies from a 2008 epidemic. Most (78%) women from coastal locations with CHIKV-specific IgG reported joint pain and stiffness; 21% reported no symptoms. CHIKV infection was significantly associated with high bodyweight. The outbreak was an isolated CHIKV epidemic without relevant DENV co-transmission.
Subjects:

Animals Antibodies, Viral Antibody Specificity Cell Line Chikungunya Virus Dengue Virus Disease Outbreaks Fever Humans Immunoglobulin G Immunoglobulin M Research Seroepidemiologic Studies
Source:

Emerg Infect Dis. 18(11):1780-1786.
Document Type:

Journal Article
Place as Subject:

Madagascar
Location:

Africa
Volume:

18
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha-512:128b35da2504335362be95b6368225a0a13366ce0b9c91607224f2dcf10d1069f1ef326f8c2a73b4bc81d671989c73b7fff6bf48d0ecc2d707f22c88a0b4526f
Download URL:

https://stacks.cdc.gov/view/cdc/18588/cdc_18588_DS1.pdf
File Type:

[PDF - 657.98 KB ]

File Language:

English

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.