Genetic Susceptibility in Pneumoconiosis

Details

• Personal Author:
  Luster MI ; Yucesoy, Berran
• Description:
  A large number of cellular mediators such as cytokines, antioxidants and growth factors have been implicatec in the pathogenesis of chronic inflammatory and fibrotic diseases. Common functional polymorphisms in these genes have been shown to influence individual susceptibility to these diseases. Silicosis, coal worker pneumoconiosis, progressive massive fibrosis and berylliosis are examples of fibrotic pneumoconiosis and are characterized by irreversible fibrotic lesions in the lung resulting. from chronic dust inhalation. Although the materials are the major contributory factors of the disease pathogenesis, not all individuals exposed to similar levels develop disease. This suggests that there is a genetic predisposition to their development. Therefore, an understanding of genetic variability and the interaction between genetic and environmental factors is crucial to the identification of high-risk individuals and prevention and treatment of these diseases. [Description provided by NIOSH]
• Subjects:
  Dust Environmental Exposure Environmental Health Environmental Pollution Fibrosis Genetics Lung Lung Diseases Occupational Diseases Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Diseases Dust-exposure Dust-particles Dusts Environmental-contamination Environmental-exposure Environmental-factors Environmental-hazards Etiology Genetic-factors Lung-disease Lung-fibrosis Lung-function Occupational-diseases Occupational-exposure Pneumoconiosis Pulmonary-system-disorders Silicosis

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• ISSN:
  0378-4274
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  249-254
• Volume:
  168
• Issue:
  3
• NIOSHTIC Number:
  nn:20031667
• Citation:
  Toxicol Lett 2007 Feb; 168(3):249-254
• Contact Point Address:
  B Yucesoy, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  yab7@cdc.gov
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cdaaca532cab8540b8d412aaaf4f3fcb7f30b9b57fe0686534149c7a6522476f8aa9583123e2ba45709fa7f2f4ac247b86257166c00d9ed68a699fef3578e067
• Download URL:
  https://stacks.cdc.gov/view/cdc/185879/cdc_185879_DS1.pdf
• File Type:
  [PDF - 166.52 KB ]