Ovulatory response of chlordecone (Kepone)-exposed mice to exogenous gonadotropins.

Details

• Personal Author:
  Eroschenko VP ; Schutzmann RL ; Swartz WJ
• Description:
  The ability of the murine ovary to ovulate in response to exogenous gonadotropins following a prolonged exposure of virgin female CD-1- mice to chlordecone (143500) was evaluated. The mice were treated daily with 2, 4, or 8mg/kg by oral gavage for 5 days/week for either 2, 4, or 6 weeks. Estradiol or sesame-oil vehicle was given to control mice for the same periods. All animals received a superovulatory regimen of the exogenous gonadotropins, pregnant mare's serum gonadotropin (PMSG) and human chorionic gonadotropin (hCG), during the final week of exposure. Highly variable effects on the ovulatory responses were noted in animals receiving the two lower doses of chlordecone with increasingly variable mean numbers of ovulated oocytes being exhibited. A significantly higher number of ovulations was produced in mice receiving the 2mg/kg dose for 6 weeks than any other treatment group. However, a significant and progressive decrease was noted in the ovulatory responses among the highest chlordecone group when compared to both control groups. The authors suggest that the effects of this high chemical dose do not arise due to the potency of its estrogenic activity, but rather through a direct effect on the ovary as sufficient exogenous gonadotropins were available to simulate ovulation. [Description provided by NIOSH]
• Subjects:
  Agriculture Hydrocarbons Insecticides Laboratories Occupational Exposure Occupational Health Safety Urogenital Diseases Urogenital System
• Keywords:
  Agricultural-chemicals Author Keywords: Chlordecone Chlorinated-hydrocarbons Chronic-exposure Fertility Gonadotropic-hormones Gonadotropins Kepone Laboratory-animals NIOSH-Grant NIOSH-Publication Ovary Ovulation Pesticides Reproductive-system-disorders

  More +
• ISSN:
  0300-483X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Louisiana ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  147-153
• Volume:
  51
• Issue:
  2
• NIOSHTIC Number:
  nn:00184454
• Citation:
  Toxicology 1988 Oct; 51(2-3):147-153
• Contact Point Address:
  Anatomy Louisiana State University 1542 Tulane Avenue New Orleans, LA 70112
• CAS Registry Number:
  Chlordecone (CAS RN 143-50-0)
• Federal Fiscal Year:
  1989
• Performing Organization:
  Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana
• Peer Reviewed:
  True
• Start Date:
  19790401
• Source Full Name:
  Toxicology
• End Date:
  19980831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:428731f73cbce4c67afaf820d58218cce630352e3cf304a0ffff8a5a413763c98df58bf5ba313e1c998b4b8b66d8a0ea8cdb761735328f62a55b63b7791f8ac5
• Download URL:
  https://stacks.cdc.gov/view/cdc/185679/cdc_185679_DS1.pdf
• File Type:
  [PDF - 370.04 KB ]