Effects of methoxychlor on the reproductive system of the adult female mouse. 1. Gross and histologic observations

Details

• Personal Author:
  Martinez EM ; Swartz WJ
• Description:
  The gross and histologic effects of methoxychlor (72435) exposure on the reproductive system were investigated in female CD-1-mice. Mice were administered methoxychlor at dose levels of 1.25, 2.5, or 5.0mg/kg via oral gavage for 5 consecutive days each week for 2 or 4 weeks. Mice were sacrificed 24 hours after the final exposure. Control groups were administered 0.025 milligrams estradiol-17beta or vehicle. Analysis indicated that a dose dependent persistent vaginal estrus was induced in methoxychlor exposed animals. The ovaries of the exposed animals weighed significantly less than those of controls. An increase was also noted in the number of atretic large follicles in the control group exposed to estrogen-17beta and in the mice treated with the two highest dose levels of methoxychlor. This finding indicated a potential reduction in the immediate fertility of the animal. The authors conclude that this chemical appears to mimic very closely the effects on the female reproductive system induced by estrogens. The authors urge caution by all adult women using such substances. [Description provided by NIOSH]
• Subjects:
  Agriculture Hazardous Substances Hydrocarbons Insecticides Laboratories Occupational Health Safety Urogenital Diseases Urogenital System
• Keywords:
  Agricultural-chemicals Chlorinated-hydrocarbons Laboratory-animals NIOSH-Grant NIOSH-Publication Reproductive-hazards Reproductive-system-disorders Toxic-effects
• ISSN:
  0890-6238
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Louisiana ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  139-147
• Volume:
  5
• Issue:
  2
• NIOSHTIC Number:
  nn:00232178
• Citation:
  Reprod Toxicol 1991 Mar; 5(2):139-147
• Contact Point Address:
  Anatomy Louisiana State University 1542 Tulane Avenue New Orleans, LA 70112
• CAS Registry Number:
  Methoxychlor (CAS RN 72-43-5)
• Federal Fiscal Year:
  1991
• Performing Organization:
  Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana
• Peer Reviewed:
  True
• Start Date:
  19790401
• Source Full Name:
  Reproductive Toxicology
• End Date:
  19980831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b10619244fa2036ab5b59404bdbcf27fbca7869f9f8688b34b363798916635d0c85f6e0f6a55158975ae58f8cd65f97849b43c8389d0187abdc48b48f3efbea5
• Download URL:
  https://stacks.cdc.gov/view/cdc/204558/cdc_204558_DS1.pdf
• File Type:
  [PDF - 1.09 MB ]