Prenatal ethylene glycol monomethyl ether (EGME) exposure produces electrocardiographic changes in the rat.

Details

• Personal Author:
  Breitenstein, Michael J. ; Toraason M
• Description:
  A study was made of electrocardiographic changes in 3 and 6 week old rats exposed in-utero to ethylene-glycol-monomethyl-ether (109864) (EGME) in order to determine if intraventricular conduction delays previously observed in fetuses would persist beyond the fetal/neonatal period. Pregnant female Sprague-Dawley-rats were treated by gavage with 0, 50, or 75mg/kg EGME on days seven through 13 of gestation. Surviving offspring at 3 and 6 weeks of age were assessed electrocardiographically in an unanesthetized, unrestrained condition. EGME treated dams had a prolonged gestation, smaller litter size, lower pup weight, and a lower percentage of dams that delivered. There was a dose related effect of EGME on pup survival, with 100 percent mortality after day one in the 75mg/kg group and about 50 percent mortality by day three in the 50mg/kg group. Surviving offspring in the low dose group weighed significantly less than controls at 8 weeks of age. EGME treated rats had slightly increased heart weights and significantly increased heart/body weight ratios, but no microscopic abnormalities were detected. Electrocardiographic changes included increased QRS intervals in 3 and 6 week old pups and significantly prolonged T-waves in 6 week old pups. Nonsignificant increases in QRS amplitude were observed in exposed offspring. Intraventricular conduction delay in one or more offspring was noted in 36 and 54 percent of 3 and 6 week old litters, respectively. The authors conclude that doses of EGME that are not maternally toxic have a severe effect on reproductive outcome, producing an intraventricular conduction delay that persists through at least 6 weeks of age. [Description provided by NIOSH]
• Subjects:
  Cardiovascular System Electrocardiography Glycols Hazardous Substances Laboratories Occupational Health Safety Urogenital System
• Keywords:
  Cardiac-function Cardiovascular-system Ethylenic-alcohols In-vivo-studies Laboratory-animals NIOSH-Author Reproductive-system Toxic-effects Transplacental-exposure
• ISSN:
  0041-008X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  321-327
• Volume:
  95
• Issue:
  2
• NIOSHTIC Number:
  nn:00183489
• Citation:
  Toxicol Appl Pharmacol 1988 Sep; 95(2):321-327
• CAS Registry Number:
  2-Methoxyethanol (CAS RN 109-86-4)
• Federal Fiscal Year:
  1988
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Applied Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:72488e4b6b0fb3a37c720c2d4ca8d406433996eba0ad6c1201e3f478e1e58945f1fb9f05b9a34ea92996b16c8c2a251c1a321d33defc5b575a10ebe7a7b9668e
• Download URL:
  https://stacks.cdc.gov/view/cdc/185662/cdc_185662_DS1.pdf
• File Type:
  [PDF - 625.29 KB ]