Zinc effects on nickel dermatitis in the guinea pig.

Details

• Personal Author:
  Angrick EJ ; Blakeslee JR ; Dorn CR ; Gerken DF ; Gordon JC ; Warner RD
• Description:
  The possibility that zinc supplementation, with zinc-sulfate in drinking water, during nickel (7440020) (Ni) sensitization and challenge effects nickel induced allergic contact dermatitis in female Hartley-guinea-pigs was investigated. A comparison was made of in-vitro lymphocyte transformation test responses with in-vivo intradermal hypersensitivity test responses in Ni exposed and nonexposed guinea-pigs. A significant affect on lymphocyte response, as measured in the lymphocyte transformation test, was noted when animals received zinc supplementation in the drinking water from 4 weeks prior to nickel exposures through the period of challenge. Oral intake of zinc-sulfate at 250 micrograms/milliliter (microg/ml) and 500microg/ml significantly lowered stimulation indices (SIs) from control levels. No significant correlation was noted between intradermal test responses and the SI values of individual guinea-pigs exposed to nickel-sulfate. No statistically different concentrations of zinc were found in the skin or whole blood for zinc supplemented groups or between nickel sensitive and nonsensitive animals within the groups. Description provided by NIOSH
• Subjects:
  • Dermatitis
  • Hypersensitivity
  • Laboratories
  • Nickel
  • Occupational Health
  • Safety
  • Skin
  • Skin Diseases
• Keywords:
  • NIOSH-Publication
  • NIOSH-Grant
  • Dermatitis
  • Laboratory-animals
  • Skin-exposure
  • Allergic-dermatitis
  • Allergic-reactions
  • Nickel-compounds
  • Contact-dermatitis
  • Author Keywords: allergy
  More +
• ISSN:
  0105-1873
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  98-108
• Volume:
  19
• Issue:
  2
• NIOSHTIC Number:
  nn:00182119
• Citation:
  Contact Dermatitis 1988 Aug; 19(2):98-108
• Contact Point Address:
  Veterinary Preventive Medicine Ohio State University 1900 Coffey Road Columbus, Ohio 43210
• CAS Registry Number:
  • Nickel (CAS RN 7440-02-0)
• Federal Fiscal Year:
  1988
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  Ohio State University, Columbus, Ohio
• Peer Reviewed:
  True
• Start Date:
  19850927
• Source Full Name:
  Contact Dermatitis
• End Date:
  19860831
• Download URL:
  https://stacks.cdc.gov/view/cdc/185626/cdc_185626_DS1.pdf
• File Type:
  [PDF - 868.80 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:964650c3f09929e1f8dc2cff74895f1dce82b40d794ca76ccc63e3c51cb7e21208da7c2071a7c8f55298d5da7c8b482378663fe6cc05fee92876657c0603eece