Zinc effects on nickel dermatitis in the guinea pig.

Details

• Personal Author:
  Angrick EJ ; Blakeslee JR ; Dorn CR ; Gerken DF ; Gordon JC ; Warner RD
• Description:
  The possibility that zinc supplementation, with zinc-sulfate in drinking water, during nickel (7440020) (Ni) sensitization and challenge effects nickel induced allergic contact dermatitis in female Hartley-guinea-pigs was investigated. A comparison was made of in-vitro lymphocyte transformation test responses with in-vivo intradermal hypersensitivity test responses in Ni exposed and nonexposed guinea-pigs. A significant affect on lymphocyte response, as measured in the lymphocyte transformation test, was noted when animals received zinc supplementation in the drinking water from 4 weeks prior to nickel exposures through the period of challenge. Oral intake of zinc-sulfate at 250 micrograms/milliliter (microg/ml) and 500microg/ml significantly lowered stimulation indices (SIs) from control levels. No significant correlation was noted between intradermal test responses and the SI values of individual guinea-pigs exposed to nickel-sulfate. No statistically different concentrations of zinc were found in the skin or whole blood for zinc supplemented groups or between nickel sensitive and nonsensitive animals within the groups. [Description provided by NIOSH]
• Subjects:
  Dermatitis Hypersensitivity Laboratories Nickel Occupational Health Safety Skin Skin Diseases
• Keywords:
  Allergic-dermatitis Allergic-reactions Author Keywords: Allergy Blocking Effect Contact-dermatitis Dietary Supplementation Guinea Pig Maximization Test Laboratory-animals Lymphocyte Transformation Test Nickel Nickel-compounds NIOSH-Grant NIOSH-Publication Skin-exposure Zinc

  More +
• ISSN:
  0105-1873
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  98-108
• Volume:
  19
• Issue:
  2
• NIOSHTIC Number:
  nn:00182119
• Citation:
  Contact Dermatitis 1988 Aug; 19(2):98-108
• Contact Point Address:
  Veterinary Preventive Medicine Ohio State University 1900 Coffey Road Columbus, Ohio 43210
• CAS Registry Number:
  Nickel (CAS RN 7440-02-0)
• Federal Fiscal Year:
  1988
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  Ohio State University, Columbus, Ohio
• Peer Reviewed:
  True
• Start Date:
  19850927
• Source Full Name:
  Contact Dermatitis
• End Date:
  19860831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:964650c3f09929e1f8dc2cff74895f1dce82b40d794ca76ccc63e3c51cb7e21208da7c2071a7c8f55298d5da7c8b482378663fe6cc05fee92876657c0603eece
• Download URL:
  https://stacks.cdc.gov/view/cdc/185626/cdc_185626_DS1.pdf
• File Type:
  [PDF - 868.80 KB ]