Extended-Spectrum β-Lactamase Genes of Escherichia coli in Chicken Meat and Humans, the Netherlands

Overdevest, Ilse; Willemsen, Ina; Rijnsburger, Martine; Eustace, Andrew; Xu, Li; Hawkey, Peter; Heck, Max; Savelkoul, Paul; Vandenbroucke-Grauls, Christina; van der Zwaluw, Kim; Huijsdens, Xander; Kluytmans, Jan

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Extended-Spectrum β-Lactamase Genes of Escherichia coli in Chicken Meat and Humans, the Netherlands

Supporting Files Public Domain

Jul 2011
By Overdevest, Ilse ; Willemsen, Ina ; Rijnsburger, Martine ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Overdevest, Ilse ; Willemsen, Ina ; Rijnsburger, Martine ; Eustace, Andrew ; Xu, Li ; Hawkey, Peter ; Heck, Max ; Savelkoul, Paul ; Vandenbroucke-Grauls, Christina ; van der Zwaluw, Kim ; Huijsdens, Xander ; Kluytmans, Jan
Description:

We determined the prevalence and characteristics of extended-spectrum β-lactamase (ESBL) genes of Enterobacteriaceae in retail chicken meat and humans in the Netherlands. Raw meat samples were obtained, and simultaneous cross-sectional surveys of fecal carriage were performed in 4 hospitals in the same area. Human blood cultures from these hospitals that contained ESBL genes were included. A high prevalence of ESBL genes was found in chicken meat (79.8%). Genetic analysis showed that the predominant ESBL genes in chicken meat and human rectal swab specimens were identical. These genes were also frequently found in human blood culture isolates. Typing results of Escherichia coli strains showed a high degree of similarity with strains from meat and humans. These findings suggest that the abundant presence of ESBL genes in the food chain may have a profound effect on future treatment options for a wide range of infections caused by gram-negative bacteria.
Subjects:

Aged Aged, 80 And Over Animals Bacteria Beta-Lactamases Chicken Meat Chickens Disease Reservoirs Drug Resistance Drug Resistance, Bacterial Enterobacteriaceae Enterobacteriaceae Infections Escherichia Coli Extended-spectrum β-lactamase Genes Feces Female Humans Klebsiella Male Meat Microbial Sensitivity Tests Middle Aged Multilocus Sequence Typing Netherlands Prevalence Prospective Studies Research The Netherlands Transmission
Source:

Emerg Infect Dis. 17(7):1216-1222.
Document Type:

Journal Article
Volume:

17
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:27fb504da8861795a3282ac7a3fe5bf89e35e1de433b36d7b8d6dcd8a59c5762
Download URL:

https://stacks.cdc.gov/view/cdc/18552/cdc_18552_DS1.pdf
File Type:

[PDF - 524.99 KB ]

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