Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Shanks, G. Dennis ; Brundage, John F.
Shanks, G. Dennis ; Brundage, John F. Less -
Description:
Of the unexplained characteristics of the 1918-19 influenza pandemic, the extreme mortality rate among young adults (W-shaped mortality curve) is the foremost. Lack of a coherent explanation of this and other epidemiologic and clinical manifestations of the pandemic contributes to uncertainty in preparing for future pandemics. Contemporaneous records suggest that immunopathologic responses were a critical determinant of the high mortality rate among young adults and other high-risk subgroups. Historical records and findings from laboratory animal studies suggest that persons who were exposed to influenza once before 1918 (e.g., A/H3Nx 1890 pandemic strain) were likely to have dysregulated, pathologic cellular immune responses to infections with the A/H1N1 1918 pandemic strain. The immunopathologic effects transiently increased susceptibility to ultimately lethal secondary bacterial pneumonia. The extreme mortality rate associated with the 1918-19 pandemic is unlikely to recur naturally. However, T-cell-mediated immunopathologic effects should be carefully monitored in developing and using universal influenza vaccines.
Subjects:
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Animals History, 19th Century History, 20th Century Humans Influenza, Human Influenza A Virus, H1N1 Subtype Influenza Pandemic, 1918-1919 Models, Biological Pandemics Perspective Pneumonia, Bacterial World War I
Source:
Emerg Infect Dis. 18(2):201-207.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:22908bedb746ade8a105c5f772728d01a0f85aec1680eea096ac17fa888b8003
Download URL:
https://stacks.cdc.gov/view/cdc/18541/cdc_18541_DS1.pdf
File Type:

Supporting Files

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