A study of ethers for the selection of candidates for carcinogen bioassay.

Details

• Personal Author:
  Atkinson DL ; Bulian ES ; Helmes CT ; McCaleb KE ; Paga PA ; Rich PA ; Sigman CC ; Thompson KL ; Valentini MA
• Description:
  To select compounds for carcinogenesis study, a class of 323 ether compounds deemed to be commercially significant was investigated. Review articles, compendia, and other reports of experimental data were used to gather evidence of potential carcinogenicity of the compounds. This original list was reduced to 176 compounds after consulting previous or currently underway carcinogenicity test results, or by determining that the compounds were not produced in the United States in commercial quantities. These 176 compounds were divided into three categories (high, moderate, or low) of potential human exposure. The 176 compounds were further subdivided into 11 chemical structure subclasses covering the range of structural configurations in these ethers. These classes were: alkoxyphenyl ethers, extended phenyl ethers, fused aryl ring system ethers, tetrahydrofurans, simple aliphatic ethers, ring containing aliphatic ethers, halophenoxyalkyl ethers, pyrans and benzopyrans, diaryl ethers, N-heterocyclic ring systems, and ethers of uncharacterized structure. Based on the suspicion of possible carcinogenic activity and evidence indicating potential exposure, the following eight chemicals were nominated for further investigation: methyleugenol (93152), isoeugenol (97541), 2- isopropoxyphenyl-N-methylcarbamate (114261), estragole (140670), 2- hydroxy-4-methoxybenzophenone (131577), tetrahydrofuran (109999), methyl-vinyl-ether (107255), and diphenyl-ether (101848). [Description provided by NIOSH]
• Subjects:
  Biological Assay Carcinogens Chemistry Environmental Exposure Environmental Pollution Ether Furans Hydrocarbons Occupational Health Safety
• Keywords:
  Aliphatic-hydrocarbons Author Keywords: Ethers Bioassay Bioassays Carclnogenicity Chemical-structure Environmental-contamination Environmental-pollution NIOSH-Author Review
• ISSN:
  0360-1226
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  6
• NIOSHTIC Number:
  nn:00175539
• Citation:
  J Environ Sci Health. Part A, Environ Sci Eng 1983 Nov-Dec; 18(6):797-839
• Contact Point Address:
  Dr. H. F. Kraybill, Scientific Coordinator of the Office for Environmental Cancer, Division of Cancer Cause and Prevention, National Cancer Institute, Landow Building, Room C337, 7910 Woodmont Avenue, Bethesda, Maryland 20205
• CAS Registry Number:
  2-Hydroxy-4-methoxybenzophenone (CAS RN 131-57-7) ; Diphenyl ether (CAS RN 101-84-8) ; Estragole (CAS RN 140-67-0) ; Isoeugenol (CAS RN 97-54-1) ; Methyl vinyl ether (CAS RN 107-25-5) ; Methyleugenol (CAS RN 93-15-2) ; Propoxur (CAS RN 114-26-1) ; Tetrahydrofuran (CAS RN 109-99-9)
• Federal Fiscal Year:
  1984
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Environmental Science and Health. Part A: Environmental Science and Engineering
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a6a1fc9a56f87369800578dc3047a2383927635eaff9a4c899b872cc905bf0fb4d1b01ab8b36aa0305f8e57285b979555aa62a33e72d985c0847e864636af323
• Download URL:
  https://stacks.cdc.gov/view/cdc/185394/cdc_185394_DS1.pdf
• File Type:
  [PDF - 1.22 MB ]