Chronic beryllium disease in the United States.

Details

• Personal Author:
  Cherniack, Martin G. ; Cullen MR ; Kominsky, John R.
• Description:
  Chronic beryllium (7440417) disease or berylliosis was reviewed with regard to occurrence, clinical signs, diagnostic strategies, and preventive measures. Lung biopsy of most cases of berylliosis occurring since 1960 showed the presence of characteristic sarcoid like epithelioid granulomas similar to those seen in cases of idiopathic sarcoidosis. Berylliosis patients and sarcoidosis patients both showed liver, skin, lymphatic, and lung involvement; suppressed T-lymphocyte function; and similar infiltrates in lung tissue. Differences between the two types of patients were discussed with respect to age, radiographic changes, and extrapulmonary manifestations of disease. Epidemiological studies showed that berylliosis was an idiosyncratic disorder requiring a host factor in addition to beryllium exposure and that disease occurrence was related to both the form and dose of beryllium exposure. Industries and trades with potential beryllium exposure included ceramics and electrical connectors, nonferrous foundries and smelters, sandblasting, aerospace, electronics, refractories, beryllium smelting and fabrication, tool and die making, soldering and welding, and hazardous waste processing (SIC-4953). The manufacture of nuclear control equipment, dental equipment and supplies (SIC-3843), engineering and scientific equipment, mechanical measuring equipment, automotive parts, and telecommunication equipment also presented some risk for berylliosis. The authors note that new exposure settings are being monitored for future control of berylliosis and secondary prevention, including the definition and validation of a sensitive diagnostic test. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution, Indoor Beryllium Hazardous Substances Irritants Lung Lung Diseases Metals, Heavy Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Air-contamination Beryllium-disease Clinical-symptoms Exposure-levels Heavy-metals Industrial-medicine Lung-lesions NIOSH-Author Occupational-exposure Respiratory-irritants Toxic-effects Worker-health

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• ISSN:
  0192-9755
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Massachusetts ; Ohio ; OSHA Region 1 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  203-209
• Volume:
  7
• Issue:
  3
• NIOSHTIC Number:
  nn:00174933
• Citation:
  Sem Respir Med 1986 Jan; 7(3):203-209
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  1986
• Peer Reviewed:
  True
• NAICS and SIC Codes:
  4953 - Refuse systems - (SIC) ; 3843 - Dental equipment and supplies - (SIC)
• Source Full Name:
  Seminars in Respiratory Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:105ca16530b6d0bb744fdade6987e477cc8bc311ed980db610f076bb51865355d0409a18980992e7548f565a72dfdcce8f29cd318e07daa64e53a038fbb425e3
• Download URL:
  https://stacks.cdc.gov/view/cdc/185354/cdc_185354_DS1.pdf
• File Type:
  [PDF - 1.17 MB ]