The toxicological implications of the interaction of butylated hydroxytoluene with other antioxidants and phenolic chemicals.

Details

• Personal Author:
  Thompson DC ; Trush MA
• Description:
  Tests were carried out to determine the toxic outcome of the interactions between butylated-hydroxytoluene (128370) (BHT) and a variety of other phenolic derivatives by investigating the in-vitro generation of BHT-quinone-methide in the presence of peroxidase enzymes, the effects of phenols on this reaction, and its in-vivo significance. In-vitro tests revealed that butylated-hydroxyanisole (25013165) (BHA) increased both the peroxidase binding of BHT to microsomal protein and the generation of BHT-quinone-methide. The metabolic activation of BHT was also promoted by eugenol (97530), methylparaben (99763), vanillin (121335), guaiacol (90051), ferulic- acid (1135246), and a series of other phenolic additives, but to a lesser degree than that induced by BHA. In-vitro studies carried out with lung, bladder, kidney medulla, and intestinal microsomes obtained from both animals and man, in the presence of hydrogen- peroxide (7722841) or arachidonic-acid (506321), supported the interaction of BHT and BHA. Subcutaneous injection of BHA to male CD- 1-mice, prior to the intraperitoneal injection of BHT, increased the ratio of lung to body weight of the animals as compared to mice treated with BHT alone. [Description provided by NIOSH]
• Subjects:
  Chemistry Digestive System Food Additives Kidney Diseases Laboratories Lung Musculoskeletal System Occupational Health Respiratory System Safety Toxicology Urogenital Diseases Urogenital System

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• Keywords:
  Bone-marrow Chemical-structure Food-additives Gastrointestinal-system In-vitro-studies Laboratory-animals Lung-function Nephrotoxicity NIOSH-Grant NIOSH-Publication
• ISSN:
  0278-6915
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  24
• Issue:
  10
• NIOSHTIC Number:
  nn:00171661
• Citation:
  Food Chem Toxicol 1986 Oct; 24(10/11):1189-1195
• CAS Registry Number:
  2,6-Di-tert-butyl-4-methylphenol (CAS RN 128-37-0) ; Arachidonic acid (CAS RN 506-32-1) ; Eugenol (CAS RN 97-53-0) ; Ferulic acid (CAS RN 1135-24-6) ; Guaiacol (CAS RN 90-05-1) ; Hydrogen peroxide (CAS RN 7722-84-1) ; Methylparaben (CAS RN 99-76-3) ; tert-Butylhydroxyanisole (CAS RN 25013-16-5) ; Vanillin (CAS RN 121-33-5)
• Federal Fiscal Year:
  1987
• Performing Organization:
  Environmental Health Sciences Johns Hopkins University 615 N Wolfe Street Baltimore, MD 21205
• Peer Reviewed:
  True
• Start Date:
  19830701
• Source Full Name:
  Food and Chemical Toxicology
• End Date:
  19850630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f8124206631d8301d2ad1a9ea8dd80b318eeae9b1b5297cf826ab6a62412e597d966467bfe8d4f0985f7a0f7d9b0ade3e8e18b0a4ca8df204713bf31a8ec0cec
• Download URL:
  https://stacks.cdc.gov/view/cdc/185258/cdc_185258_DS1.pdf
• File Type:
  [PDF - 595.79 KB ]