Total and regional deposition of inhaled aerosols in humans.

Details

• Personal Author:
  Diu CK ; Yu CP
• Description:
  A model was developed for the deposition of inhaled aerosols in the various regions of the human respiratory tract, and the results obtained were compared with earlier experimental findings which demonstrated that the total deposition of a spherical, uncharged aerosol depended on the diameters, densities, flow rates and residence time of the particles. A deposition parameter combining all the physical factors, so that the deposition could be expressed as a function of this parameter alone, was described. The model gave an accurate estimate of total and regional aerosol depositions in the respiratory tract for a wide range of breathing conditions, particle diameters and mass densities. The results obtained correlated well with the experimental findings of others. Detailed examination of the role played by flow rate revealed that total deposition increased according to flow rate because of increased deposition due to impaction. At a flow rate greater than 500 cubic centimeters per second (cm3/sec), the increase in total deposition was due to increased impaction in the head and tracheobronchial tree, while alveolar deposition remained practically unchanged. A sharp increase in alveolar deposition was determined at increasing flow rates from 250 to 500cm3/sec, due to longer residence time and deeper aerosol penetration. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Lung Occupational Health Particulate Matter Respiratory System Safety Somatotypes
• Keywords:
  Aerosol-particles Airborne-particles Body-distribution Body-regions Body-retention Humans Lung-function Mathematical-models NIOSH-Grant NIOSH-Publication Physiological-measurements Pulmonary-clearance

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• ISSN:
  0021-8502
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maine ; New York ; OSHA Region 1 ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  5
• NIOSHTIC Number:
  nn:00169980
• Citation:
  J Aerosol Sci 1983 Jan; 14(5):599-609
• Contact Point Address:
  Engineering Science S U N Y - at Buffalo Dept of Engineering Science Buffalo, N Y 14214
• Federal Fiscal Year:
  1983
• Performing Organization:
  State University of New York at Buffalo, Buffalo, New York
• Peer Reviewed:
  True
• Start Date:
  19791201
• Source Full Name:
  Journal of Aerosol Science
• End Date:
  19861130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3732ee6eb2f36aaf741b76eccdb27d7a2653e2b6baa4a595d6cb8e894052f4dca1d08b05fbf2113d210b3c3f9cf575b914db2a5d9cdc54d7ca45e13a0ee340cb
• Download URL:
  https://stacks.cdc.gov/view/cdc/185205/cdc_185205_DS1.pdf
• File Type:
  [PDF - 491.75 KB ]