Comparative mutagenicity studies of azo dyes and their reduction products in Salmonella typhimurium.

Details

• Personal Author:
  Krishna G ; Nath J ; Xu J
• Description:
  The mutagenic potentials of the azo dyes, direct-black-38 (1937377), direct-blue-15 (2429745), and direct-red-2 (992596), and their aromatic amine reduction products were tested employing the Ames test and the arabinose resistant assay of Salmonella-typhimurium. S9 fractions were prepared from the livers of Sprague-Dawley-rats and Syrian-golden-hamsters, and S-typhimurium strains (TA-98) and (SV-50) were used in the mutagenicity tests. All three azo dyes tested were mutagenic in both the Ames and arabinose resistant assays; however the Ames test yielded relatively higher mutagenic responses than the arabinose resistant assay. Relatively higher mutagenic responses were observed with hamster S9 than with rat S9 in both assays. Direct-black-38 produced higher mutagenic responses in both assays than the other two dyes. The reduction products, benzidine (92875), o-dianisidine (119904), and o-tolidine (119937) were all mutagenic in the Ames test. In the arabinose resistant assay, benzidine was only weakly mutagenic, and o-dianisidine and o- tolidine were nonmutagenic. The authors conclude that both the Ames test and arabinose resistant assay are sensitive in testing the mutagenicity of azo dyes, but the Ames test is more efficient than the arabinose resistant assay in detecting mutagenicity of the aromatic amine reduction products of these dyes. [Description provided by NIOSH]
• Subjects:
  Amines Carcinogens Coloring Agents Cosmetics Microbiology Mutagens Occupational Health Pharmacies Safety Textile Industry
• Keywords:
  Azo-dyes Carcinogenicity Cosmetics-industry Food-colors Microorganisms NIOSH-Author Pharmaceutical-industry Textiles-industry
• ISSN:
  0098-4108
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  111-119
• Volume:
  18
• Issue:
  1
• NIOSHTIC Number:
  nn:00167978
• Citation:
  J Toxicol Environ Health 1986 Jan; 18(1):111-119
• CAS Registry Number:
  4,4'-Diaminodiphenyl (CAS RN 92-87-5) ; Dianisidine (CAS RN 119-90-4) ; Direct Black 38 (CAS RN 1937-37-7) ; Direct Blue 15 (CAS RN 2429-74-5) ; o-Tolidine (CAS RN 119-93-7) ; Rirect Red 2 (CAS RN 992-59-6)
• Federal Fiscal Year:
  1986
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:22e2e919f571c784ea7e9515b29f6ef421fd465d771e622ab36aaf14d664d5195924255808152f4240064189a7f35cf7f32af288bb870760801ea0d2c52cf795
• Download URL:
  https://stacks.cdc.gov/view/cdc/185152/cdc_185152_DS1.pdf
• File Type:
  [PDF - 656.87 KB ]