Toxicity data for establishing "Immediately Dangerous to Life or Health" (IDLH) values.

Details

• Personal Author:
  Allen SD ; Daniels AU ; Price NH ; Yates WG
• Description:
  Rats and guinea pigs (ten of each) were individually exposed to 30 minute inhalation tests using industrial chemicals to develop Immediately Dangerous to Life or Health (IDLH) Values. The no effect (NE) level concentration was defined as that concentration producing none of the following treatment related effects in any animal: death, irreversible pathological lesions, or impaired escape ability during the exposure. The minimal effect (ME) level was defined as that concentration producing one or more of the treatment related effects in one or two animals regardless of sex or species. The frank effect (FE) level was defined as that concentration producing one or more of the treatment related effects in three or more animals regardless of sex or species. Findings for the chemicals tested were as follows: 1,2,3-trichloropropane (96184), NE at 799 parts per million (ppm) and FE at 2,080ppm; monochlorobenzene (108907), NE at 2,990 and FE at 5,850ppm; 1,1,2,2- tetrachloroethane (79345), NE at 576ppm and FE at 5,050ppm; 3- chloropropene (107051), NE at 1,300 and 11,800ppm; N,N- dimethylaniline (121697), NE at 194 and 953ppm; 1,1,2,2- tetrabromoethane (79276), NE at 19.9 and 91.1ppm; dimethoxymethane (109875), NE at 2,810 and 8,540ppm; and phenol (108952), NE at 187ppm and FE at 540ppm. [Description provided by NIOSH]
• Subjects:
  Chlorine Compounds Inhalation Exposure Laboratories Occupational Health Safety Solvents
• Keywords:
  Chemical-industry-workers; Contract-210-76-0143 Inhalants Laboratory-animals NIOSH-Contract Organo-chlorine-compounds
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Report
• Place as Subject:
  OSHA Region 8 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:00165805
• NTIS Accession Number:
  PB87-163531
• Citation:
  University of Utah Research Institute, Salt Lake City, Utah, UBTL Division, Report TR 1510-005 1978 Aug; :1-247
• CAS Registry Number:
  1,1,2,2-Tetrabromoethane (CAS RN 79-27-6) ; 1,1,2,2-Tetrachloroethane (CAS RN 79-34-5) ; 1,2,3-Trichloropropane (CAS RN 96-18-4) ; Allyl chloride (CAS RN 107-05-1) ; Chlorobenzene (CAS RN 108-90-7) ; Dimethoxymethane (CAS RN 109-87-5) ; N,N-Dimethylaniline (CAS RN 121-69-7) ; Phenol (CAS RN 108-95-2)
• Federal Fiscal Year:
  1978
• Peer Reviewed:
  False
• Source Full Name:
  University of Utah Research Institute, Salt Lake City, Utah, UBTL Division, Report TR 1510-005
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b7c4d0cb303f789a3e8441dd67e4e0bb09e18ce97eba6ee1897886db3d22b17c963129598921254e7a89a7dd49a3d42f0807b858a1dc15c85a8cf208bfcd4de7
• Download URL:
  https://stacks.cdc.gov/view/cdc/185074/cdc_185074_DS1.pdf
• File Type:
  [PDF - 4.04 MB ]