Detection of IgE-mediated respiratory sensitization in workers exposed to hexahydrophthalic anhydride.

Details

• Personal Author:
  Bernstein DI ; Bernstein IL ; Burroughs HE ; Gallagher JS ; Moller DR ; Wilcox, Thomas G.
• Description:
  Twenty seven workers with occupational exposures to hexahydrophthalic-anhydride (85427) (HHPA) were studied to evaluate the nature of their reported respiratory complaints. Workers completed questionnaires on symptoms and family and personal medical histories. Typical worker exposures were examined. Pre and post shift pulmonary function testing was performed. Immunologic evaluation included radioimmunoassays. Work area monitoring revealed HHPA concentrations from 0.1 to 1.3 parts per million (ppm). Seven of the 27 workers reported asthma symptoms; 4 gave clear histories of occupational asthma. Fifteen other workers reported nasal and ocular symptoms. Pulmonary function testing demonstrated no airway obstruction on pre shift testing, no significant decrements in pulmonary function in post shift testing, and no significant change in forced expiratory volume in 1 second performed on the second work day morning. Specific immunoglobulin-E (IgE) to HHPA human serum albumin (HSA) was detected in 44 percent of workers examined. Seven worked in a high HHPA exposure area and the other five were from adjacent work areas. The seven radioallergosorbent (RAST) positive workers from the HHPA area had worked there for an average of 4.2 years while the 14 RAST negative workers from the same area had worked an average of 1.6 years. All four workers with occupational asthma demonstrated high titers of HHPA/HSA specific IgE, ranging from 8.7 to 23.4 percent. Three workers with symptoms of asthma not clearly associated with the workplace did not have significantly elevated specific IgE titers. Solid phase bead radioimmunoassay detected all positive sera. Specific immunoglobulin-G to HHPA/HSA was demonstrated in 11 of 27 workers. The authors conclude that HHPA should be included in the list of phthalyl anhydrides that cause IgE mediated respiratory disease. [Description provided by NIOSH]
• Subjects:
  Diagnosis Lung Lung Diseases Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Clinical-diagnosis Clinical-symptoms Exposure-levels Exposure-limits Gas-detectors Health-standards Industrial-chemicals Lung-irritants Lung-lesions NIOSH-Author Occupational-exposure

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• ISSN:
  0091-6749
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  75
• Issue:
  6
• NIOSHTIC Number:
  nn:00153349
• Citation:
  J Allergy Clin Immunol 1985 Jun; 75(6):663-672
• CAS Registry Number:
  Hexahydrophthalic anhydride (CAS RN 85-42-7)
• Federal Fiscal Year:
  1985
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Allergy and Clinical Immunology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:461be76dbf38f6ace60d36115db5050ec1a0c115a862b9a0658c953f0aff9c9df32238ca391d06b835c4ddb59c2e348304b31df3281e8e0714c6f9d145aaec76
• Download URL:
  https://stacks.cdc.gov/view/cdc/184901/cdc_184901_DS1.pdf
• File Type:
  [PDF - 969.94 KB ]