Binary Toxin and Death after Clostridium difficile Infection

Bacci, Sabrina; Mølbak, Kåre; Kjeldsen, Marianne K.; Olsen, Katharina E.P.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Binary Toxin and Death after Clostridium difficile Infection

Published Date:

Jun 2011

Source:

Emerg Infect Dis. 17(6):976-982.

[PDF - 172.95 KB]

Details:

Personal Authors:

Bacci, Sabrina ; Mølbak, Kåre ; Kjeldsen, Marianne K. ; Olsen, Katharina E.P. ;

Keywords:

[+]

Description:

We compared 30-day case-fatality rates for patients infected with Clostridium difficile possessing genes for toxins A and B without binary toxin (n = 212) with rates for patients infected with C. difficile possessing genes for A, B, and binary toxin. The latter group comprised patients infected with strains of PCR ribotype 027 (CD027, n = 193) or non-027 (CD non-027, n = 72). Patients with binary toxin had higher case-fatality rates than patients without binary toxin, in univariate analysis (relative risk [RR] 1.8, 95% confidence interval [CI] 1.2-2.7) and multivariate analysis after adjustment for age, sex, and geographic region (RR 1.6, 95% CI 1.0-2.4). Similar case-fatality rates (27.8%, 28.0%) were observed for patients infected with CD027 or CD non-027. Binary toxin either is a marker for more virulent C. difficile strains or contributes directly to strain virulence. Efforts to control C. difficile infection should target all virulent strains irrespective of PCR ribotype.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

10-1483-F1.gif	image/gif
10-1483-F1.jpg	image/jpeg
10-1483-F2.gif	image/gif
10-1483-F2.jpg	image/jpeg
10-1483_finalR.nxml	text/plain
license.txt	text/plain

No Related Documents.

You May Also Like:

Clostridium difficile Infection Caused by Binary Toxin–Positive Strains

Personal Author:

Hensgens, Marjolein P.M.; Kuijper, Ed J.;

Published:

2013

Source:

Emerg Infect Dis. 19(9):1539-1540.

File Type:

[PDF - 357.85 KB]
Attributing Cause of Death for Patients with Clostridium difficile Infection

Personal Author:

Gilca, Rodica; Frenette, Charles; Thériault, Nathanaëlle; Fortin, Élise; Villeneuve, Jasmin;

Published:

Oct 2012

Source:

Emerg Infect Dis. 18(10):1707-1708.

File Type:

[PDF - 164.18 KB]
Increasing hospitalization and death possibly due to Clostridium difficile diarrheal disease.

Personal Author:

Frost, F.; Craun, G. F.; Calderon, R. L.;

Published:

1998 Oct-Dec

Source:

Emerg Infect Dis. 4(4):619-625.

Description:

This study calculated yearly estimated national hospital discharge (1985 to 1994) and age-adjusted death rates (1980 to 1992) due to bacterial, viral, protozoal, and ill-defined enteric pathogens. Infant and young child hospitalization (but not death...

File Type:

[PDF - 88.05 KB]
Risk for Clostridium difficile Infection After Allogeneic Hematopoietic Cell Transplant Remains Elevated in the Postengraftment Period

Personal Author:

Dubberke, Erik R.; Reske, Kimberly A.; Olsen, Margaret A.; Bommarito, Kerry M.; Seiler, Sondra; Silveira, Fernanda P.; Chiller, Tom M.; DiPersio, John; Fraser, Victoria J.;

Published:

Mar 17 2017

Source:

Transplant Direct. 2017; 3(4).

Description:

Background : Clostridium difficile infection (CDI) is a frequent cause of diarrhea among allogeneic hematopoietic cell transplant (HCT) recipients. It is unknown whether risk factors for CDI vary by time posttransplant. : Methods : We performed a 3-y...

File Type:

[PDF - 197.25 KB]
Environmental transmission of Clostridium difficile: association between hospital room square footage and C. difficile infection

Personal Author:

Jou, Justine; Ebrahim, John; Shofer, Frances S.; Hamilton, Keith W.; Stern, John; Han, Jennifer H.;

Published:

Feb 05 2015

Source:

Infect Control Hosp Epidemiol. 36(5):564-568.

Description:

Background : The hospital environment is important in the transmission of Clostridium difficile, with C. difficile frequently contaminating environmental surfaces. Our objective was to evaluate the association between hospital room square footage and...

File Type:

[PDF - 113.71 KB]