Comparative inhalation teratogenicity of four glycol ether solvents and an amino derivative in rats.

Details

• Personal Author:
  Brightwell WS ; Goad PT ; Kuczuk MH ; Mathinos PR ; Nelson BK ; Setzer JV ; Weaver TE
• Description:
  The teratogenicity of inhaled glycol ether solvents and 2- methylaminoethanol (109831) was compared in rats. Pregnant Sprague- Dawley-rats were exposed on gestation days 7 through 15 for 7 hours a day to concentrations not considered toxic to dams of roughly 50, 100 or 200 parts per million (ppm) methoxyethanol (109864), 150 or 200ppm butoxyethanol (111762), 130, 190 or 600ppm ethoxyethyl- acetate (1608726), 100ppm 2-ethoxyethanol (110805) or 150ppm 2- methylaminoethanol. Dams were killed on day 20 and fetuses and resorption sites examined. Neither 2-ethoxyethanol nor 2- methylaminoethanol was embryotoxic. At 200ppm 2-methoxyethanol was highly embryotoxic, producing complete resorptions. At 100 and 50ppm it caused increased resorption, reduced fetal weight and skeletal and cardiovascular defects. At 600ppm 2-ethoxyethyl- acetate induced complete resorption of litters while 390ppm reduced fetal weight and caused skeletal and cardiovascular defects. Only one defect was seen at 130ppm. There were signs of slight maternal toxicity at 200ppm 2-butoxyethanol but no congenital defects resulted at either concentration. The authors conclude that the shorter alkyl chain glycol ethers are more embryotoxic than those with longer chains. The lack of teratogenicity of 2- methylaminoethanol points to a relatively strict structural requirement to produce embryotoxic effects. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Dust Inhalation Exposure Occupational Exposure Occupational Health Particulate Matter Safety Teratogenesis
• Keywords:
  Airborne-dusts Airborne-particles Industrial-chemicals Inhalants Monitoring-systems Monitors NIOSH-Author Occupational-exposure Organic-chemicals Teratogens Teratology

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• ISSN:
  0091-6765
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  261-271
• Volume:
  57
• NIOSHTIC Number:
  nn:00145240
• Citation:
  Environ Health Perspect 1984 Aug; 57:261-271
• CAS Registry Number:
  2-(Methylamino)ethanol (CAS RN 109-83-1) ; 2-Butoxyethanol (CAS RN 111-76-2) ; 2-Methoxyethanol (CAS RN 109-86-4) ; Ethanol, 1-ethoxy-, 1-acetate (CAS RN 1608-72-6) ; Glycol monoethyl ether (CAS RN 110-80-5)
• Federal Fiscal Year:
  1984
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Health Perspectives
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7c18725592c5f637aff8ac627b6010b90ef645d1bd683c5cbc06109cd0a4971389622501d03c573aa1536198c7b4d3435670440c83d60a057c129f697b58a8d6
• Download URL:
  https://stacks.cdc.gov/view/cdc/184810/cdc_184810_DS1.pdf
• File Type:
  [PDF - 1.64 MB ]