Neurobehavioral assessment of chronic low-level methyl bromide exposure in the rabbit.

Details

• Personal Author:
  Anger WK ; Brightwell WS ; Russo, John M. ; Setzer JV
• Description:
  Neurobehavioral effects of methyl-bromide (74839) were studied in adult male New-Zealand-white-rabbits. Six rabbits were exposed via inhalation to 27 parts per million methyl-bromide over a period of 8 months, for a total exposure duration of 900 hours. Two control rabbits breathed filtered room air. Biweekly neurobehavioral tests examined the latency rates of the sciatic and ulnar nerves and the amplitude of the eye blink reflex of the orbicularis oculi muscle. Body weights were measured, and feeding and grooming behaviors were observed. Mean latency rates of the sciatic and ulnar nerves of the exposed animals failed to exhibit the anticipated decline characteristic of peripheral nervous system impairment produced by methyl-bromide. Results of eye blink reflex testing also failed to reveal reliable differences that could be attributed to the exposures. Rabbits in the exposed group gained steadily in weight. Control animals also gained weight. No systematic changes in feeding or grooming behaviors were observed. The authors conclude that neurological impairment is not a prominent feature of chronic exposure to low concentrations of methyl-bromide. [Description provided by NIOSH]
• Subjects:
  Animals Behavior Hazardous Substances Nervous System Occupational Health Safety Toxicology
• Keywords:
  Animal-studies Behavioral-testing Biological-effects Industrial-chemicals Medical-research Nerve-function Neurophysiological-effects Neurotoxic-effects NIOSH-Author Quantitative-analysis Toxic-vapors

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• ISSN:
  0098-4108
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  247-255
• Volume:
  14
• Issue:
  2
• NIOSHTIC Number:
  nn:00144957
• Citation:
  J Toxicol Environ Health 1984 Jan; 14(2-3):247-255
• CAS Registry Number:
  Methyl bromide (CAS RN 74-83-9)
• Federal Fiscal Year:
  1984
• NORA Priority Area:
  Neurotoxic Effects
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4a212b1a3183e2b92b824265b91f40b67693aea406ae74c2be8b6b4eff2c58fca467b6dc02a9c472c538e0951f06d2c529a4ef2aae2a66ddd8acb61f9eb1a338
• Download URL:
  https://stacks.cdc.gov/view/cdc/184807/cdc_184807_DS1.pdf
• File Type:
  [PDF - 648.22 KB ]