Evaluation of arsenic metabolites for prenatal effects in the hamster.

Details

• Personal Author:
  Harrison WP ; Hood RD ; Vedel GC
• Description:
  The fetal toxicity and teratogenicity of methylated arsenicals were investigated in hamsters. Pregnant female golden-Syrian-hamsters were injected intraperitoneally with a single dose of 500 milligrams per kilogram (mg/kg) disodium-methanearsonate (144218) (DSMA) or 900mg/kg sodium-cacodylate (124652) (NaCA) on one day each of gestation days 8 through 12. Animals were killed on gestation day 15, their livers were weighed, and uterine contents were examined. Neither treatment resulted in altered maternal liver/body weight ratios. NaCA produced its greatest effects on day 9, with 70 percent of litters totally resorbed, 94.8 percent prenatal mortality, and 100 percent of fetuses grossly malformed. Gross malformation, observed in fetuses from all NaCA treatment groups except day 12, included cleft palate, cleft lip, micromelia, syndactyly, exencephaly, and talipes. Fused ribs were detected in the day 8, 9, and 10 NaCA groups. DSMA produced its greatest effects on day 12 with one litter totally resorbed, a prenatal mortality of 20.5 percent, and one fetus grossly malformed. Treatment on days 9, 10, or 12 was followed by fetal stunting. Only three cases of gross malformations were seen: exencephaly; lateral cleft lips; and a short muzzle. The authors conclude that methylation of arsenic greatly reduces its toxicity to adult animals. Both monomethylated and dimethylated arsenicals exhibit less toxicity to the hamster conceptus than would be expected for inorganic arsenic. [Description provided by NIOSH]
• Subjects:
  Animals Metals Metals, Heavy Occupational Health Poisoning Safety Teratogenesis Toxicology Urogenital Diseases Urogenital System
• Keywords:
  Animal-studies Biological-effects Comparative-toxicology Embryotoxicity Heavy-metal-poisoning Medical-research NIOSH-Grant NIOSH-Publication Reproductive-hazards Teratogens
• ISSN:
  0007-4861
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  29
• Issue:
  6
• NIOSHTIC Number:
  nn:00140279
• Citation:
  Bull Environ Contam Toxicol 1982 Dec; 29(6):679-687
• Contact Point Address:
  Biology University of Alabama Post Office Box 1927 University, Ala 35486
• CAS Registry Number:
  Disodium methylarsonate (CAS RN 144-21-8) ; Sodium cacodylate (CAS RN 124-65-2)
• Federal Fiscal Year:
  1983
• NORA Priority Area:
  Reproductive System Disorders
• Performing Organization:
  University of Alabama IN University, University, Alabama
• Peer Reviewed:
  True
• Start Date:
  19790501
• Source Full Name:
  Bulletin of Environmental Contamination and Toxicology
• End Date:
  19850630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f514843f76088d5d8a8d64b0ac0665646df58f5dba2f7763b0eefe731ad9f2fcb1289830507733fcfe9ab76c3e4a9fad46da049ce27ac2f9557e124e00b84280
• Download URL:
  https://stacks.cdc.gov/view/cdc/184743/cdc_184743_DS1.pdf
• File Type:
  [PDF - 406.99 KB ]