Occupational risks of pesticide exposure for females. Terminal progress report.

Details

• Personal Author:
  Swartz WJ ; Swartz WJ
• Description:
  The effects of pesticides on the female reproductive system were studied in chick embryos and mice. Carbaryl (63252) was administered to chick embryos in doses of 1.0 to 10.0 milligrams (mg) for 5 or 12 days. When exposed for 12 days, carbaryl became increasingly embryotoxic and abnormalities such as subcutaneous edema and defects in the hind limbs were observed. Female mice were given 50mg per kilogram (kg) DDT (50293) orally once a week for 4 weeks. They were then treated with gonadotropins. Exposed mice did not ovulate in response to the gonadotropins. In acute experiments, virgin female mice were administered 10 to 300mg/kg DDT daily for 5 days. They were then treated with exogenous gonadotropins and ovaries were examined. Only mice receiving 10 or 50mg/kg DDT survived the experiment. A significant reduction in the number of oocytes ovulated in response to the gonadotropins occurred. Mice were treated with malathion (121755) using the same protocol as with DDT. Malathion did not affect the number of eggs ovulated in response to gonadotropins. The author concludes that DDT has a significant effect on the female reproductive system. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Animals Insecticides Occupational Health Safety Teratogenesis Toxicology Urogenital Diseases Urogenital System
• Keywords:
  NIOSH-Grant; Animal-studies; Pesticides-and-agricultural-chemicals; Reproductive-hazards; Teratogens; Biological-effects; Toxicology; Comparative-toxicology; Medical-research
• Series:
  Grant Final Reports   ; Grant Final Reports  
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report ; Final Grant Report
• Place as Subject:
  Louisiana ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs ; OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  1-13
• NIOSHTIC Number:
  nn:00134967
• NTIS Accession Number:
  PB84241645
• Citation:
  Louisiana State Univ Med Ctr, New Orleans Louisiana, 1982 Jan; :1-13
• CAS Registry Number:
  Carbaryl (CAS RN 63-25-2) ; DDT (CAS RN 50-29-3) ; Malathion (CAS RN 121-75-5) ; Carbaryl (CAS RN 63-25-2) ; DDT (CAS RN 50-29-3) ; Malathion (CAS RN 121-75-5)
• Federal Fiscal Year:
  1982
• Performing Organization:
  Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana
• Peer Reviewed:
  False
• Start Date:
  19790401
• Source Full Name:
  Louisiana State Univ Med Ctr, New Orleans Louisiana
• End Date:
  19980831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246073/cdc_246073_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]