Reproductive toxicity of the glycol ethers.

Details

• Personal Author:
  Hardin, Bryan D.
• Description:
  Reproductive toxicity of glycol ethers is reviewed. Evidence for testicular toxicity of ethylene-glycol-monomethyl-ether (109864) (EGME), ethylene-glycol-monomethyl-ether-acetate (110496), ethylene- glycol-monoethyl-ether (110805) (EGEE), ethylene-glycol-monoethyl- ether-acetate (111159), diethylene-glycol-monoethyl-ether (111900), and diethylene-glycol-dimethyl-ether (111966) is discussed. Hematological, testicular, and lymphoid effects in rats and mice exposed to EGME are discussed. The results of 2 year feeding studies with rats fed ethylene-glycol and diethylene-glycol are reviewed. The lack of adverse effects in pregnant rats treated with EGEE either orally or subcutaneously is cited. Similar results with mice and rabbits are presented. Dose dependent intrauterine fetal death in pregnant mice treated with EGME is discussed. Skeletal defects are also mentioned. Dose related incidences of intrauterine death resulting from oral doses of ethylene-glycol-dimethyl-ether are discussed. Inhalation studies on EGEE with rabbits and rats are reviewed. Behavioral teratology studies with rats exposed to EGEE are discussed. The effects of dermal application of EGEE to pregnant rats are reviewed. A discussion of prolonged gestation in animals exposed to some glycol ethers is presented. A list of published reports on reproductive effects of glycol ethers is included. [Description provided by NIOSH]
• Subjects:
  Ether Hazardous Substances Laboratories Occupational Health Safety Skin Urogenital Diseases Urogenital System
• Keywords:
  Biological-effects Ethers Immunotoxins Laboratory-animals Reproductive-hazards Skin-exposure Testes Toxic-effects Transplacental-exposure
• ISSN:
  0300-483X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  91-102
• Volume:
  27
• Issue:
  2
• NIOSHTIC Number:
  nn:00139793
• Citation:
  Toxicology 1983 Jun; 27(2):91-102
• Contact Point Address:
  Bryan D. Hardin, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, 4676 Columbia Parkway, Cincinnati, OH 45226 (U.S.A.)
• CAS Registry Number:
  2-Methoxyethanol (CAS RN 109-86-4) ; Diethylene glycol monoethyl ether (CAS RN 111-90-0) ; Diglyme (CAS RN 111-96-6) ; Ethylene glycol monomethyl ether acetate (CAS RN 110-49-6) ; Glycol monoethyl ether (CAS RN 110-80-5) ; Glycol monoethyl ether acetate (CAS RN 111-15-9)
• Federal Fiscal Year:
  1983
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2c6c6c6b3315fc3fab2b5946426f3112c005de6dff73909cdf774bb3e20e209cfd5ae6a4d27181b3b8027c2c7f30a4feb28b186bb21a425b3903f1f7e5013d44
• Download URL:
  https://stacks.cdc.gov/view/cdc/184742/cdc_184742_DS1.pdf
• File Type:
  [PDF - 773.33 KB ]