Vinyl-chloride-induced liver disease. From idiopathic portal hypertension (Banti's Syndrome) to angiosarcomas.

Details

• Personal Author:
  Berk PD ; Falk H ; Popper H ; Selikoff I ; Thomas LB
• Description:
  The effect of vinyl-chloride (75014) (VC) on liver disease among exposed workers was histologically investigated. Specimens of liver tissue were examined. Eighteen of these showed angiosarcoma. Eight samples were from autopsies and 10 were from biopsy examinations. Another five samples were from patients with hepatic fibrosis without known angiosarcoma. These were obtained from surgical and needle biopsy. Observations of the splenic changes were made on three surgical and two autopsy specimens. Sinusoidal, papillary and cavernous patterns were evident in the angiosarcomas. In addition, 25 percent of the angiosarcomas had more solid nodules of anaplastic sarcoma. In three other patients, other organs beside the liver showed evidence of angiosarcoma: the lung, heart, kidney, and lymph nodes in one patient; the duodenum in another patient; and the lung in a third patient. The patients with hepatic fibrosis had proliferation of bile ducts, single hepatocytes, and groups of hepatocytes at the margins of the portal tracts. Some of the walls of portal vein branches showed focal fibrosis. The splenic changes showed enlargement, hyperplastic Malphigian follicles, and widened red pulp sinuses. The authors conclude that the relationship between hepatic angiosarcomas and exposure to vinyl-chloride has been established. Many vinyl-chloride workers have identical symptoms resembling Banti's syndrome; inconspicuous hepatic fibrosis, splenomegaly, and portal hypertension. Banti's syndrome may result from environmental exposure to chemicals, possibly vinyl- chloride. [Description provided by NIOSH]
• Subjects:
  Chemistry Digestive System Digestive System Diseases Hazardous Substances Liver Neoplasms Occupational Exposure Occupational Health Plastics Polymers Respiratory Tract Diseases Safety Toxicology Vinyl Chloride

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• Keywords:
  Chemical-properties Hepatotoxicity Histopathology In-vivo-study Liver-cancer Liver-cells Liver-damage Liver-disorders Monomers NIOSH-Grant NIOSH-Publication Occupational-exposure Plastics-industry Polymerization Pulmonary-system-disorders Toxic-effects Vinyl-plastics

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• ISSN:
  0028-4793
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  17-22
• Volume:
  292
• Issue:
  1
• NIOSHTIC Number:
  nn:00129733
• Citation:
  N Engl J Med 1975 Jan; 292(1):17-22
• Contact Point Address:
  Community Medicine Mount Sinai School of Medicine Fifth Avenue and 100 Street New York, N Y 10029
• CAS Registry Number:
  Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  1975
• Performing Organization:
  Mount Sinai School of Medicine, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19700501
• Source Full Name:
  New England Journal of Medicine
• End Date:
  19790630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:671818a7313f3d1316bd1ca860ccd354abb4e0c1610357a44c5edc83696d99054125aaef12f8e7972dabe85f3a5b3628ca79da3aeb028b44586709ef78cd1517
• Download URL:
  https://stacks.cdc.gov/view/cdc/184615/cdc_184615_DS1.pdf
• File Type:
  [PDF - 9.34 MB ]