Hairless mice as models for chloracne: a study of cutaneous changes induced by topical application of established chloracnegens.

Details

• Personal Author:
  Ertl DC ; Puhvel SM ; Reisner RM ; Sakamoto M
• Description:
  Cutaneous changes induced by topical application of established chloracnegens were studied in female SKh:HR-1-hairless-mice and HRS/J-hairless-mice. Solutions of 0.1 milliliter of polychlorinated naphthalenes, polychlorinated biphenyls and 2,3,7,8- tetrachlorodibenzo-p-dioxin (1746016) were dissolved in acetone and applied to the dorsal skin of the mice for a treatment period ranging from 2 to 10 weeks. The cutaneous changes were monitored during this time with punch biopsies of treated skin taken for histologic studies at regular intervals. Mice were killed at the end of the treatment. Most chloracnegens caused a pattern of cutaneous pathology without associated hyperkeratinization of the sebaceous follicles. Only 3,4,3',4' tetrachlorobiphenyl induced a true chloracne like syndrome. This syndrome caused massive hyperkeratosis of the sebaceous follicles and hyperkeratinization of intradermal pilar cysts further compounded by gross weight gain. [Description provided by NIOSH]
• Subjects:
  Biochemistry Chemistry Chemistry, Analytic Laboratories Occupational Health Safety
• Keywords:
  Analytical-chemistry Analytical-methods Biochemical-tests Chemical-analysis Histochemical-analysis Laboratory-animals Laboratory-techniques NIOSH-Grant NIOSH-Publication
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  492-503
• Volume:
  64
• Issue:
  3
• NIOSHTIC Number:
  nn:00126680
• Citation:
  Toxicol Appl Pharmacol 1982 Jul; 64(3):492-503
• Contact Point Address:
  Medicine University of California 405 Hilgard Avenue Los Angeles, Calif 90024
• CAS Registry Number:
  2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6)
• Federal Fiscal Year:
  1982
• Performing Organization:
  University of California Los Angeles, Los Angeles, California
• Peer Reviewed:
  True
• Start Date:
  19800929
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19870630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a943b56164263f02360d6a8dfd5815382b5916c5f50e2e70f9cc87807a6e95527b7f8564eb3c92708263cc5b0639f743f1181b289c04b2469ae7d90e9024c253
• Download URL:
  https://stacks.cdc.gov/view/cdc/184589/cdc_184589_DS1.pdf
• File Type:
  [PDF - 1.09 MB ]