Effect of topical application of defined constituents of coal tar on skin and liver aryl hydrocarbon hydroxylase and 7-ethoxycoumarin deethylase activities.

Details

• Personal Author:
  Bickers DR ; Cherniack E ; Kushner DM ; Link CM ; Mukhtar H
• Description:
  The effect of topical application of defined constituents of coal-tar (8007452) (CT) on skin and liver aryl-hydrocarbon-hydroxylase (AHH) and 7-ethoxycoumarin-O-deethylase (7EO-d) activities was investigated. Neonatal rats received a single topical application of 100 microliters CT dissolved in acetone or benzene at a dose of 1 millogram per 10 grams. Twenty four hours after the CT application, the animals were killed and a 9000 gram supernatant fraction of each tissue was prepared. The topical application resulted in AHH induction and 7EO-d activities in skin, lung, kidney, intestine, and liver. In descending order AHH induction was maximal in skin, liver, intestine, lung and kidney. 7EO-d inducibility was highest in the lung. The authors suggest that CT inhalation could affect tumor induction in the lung. [Description provided by NIOSH]
• Subjects:
  Laboratories Neoplasms Occupational Health Safety Skin Skin Diseases Toxicology
• Keywords:
  Laboratory Animals Skin Cancer Skin Disorders Skin Infections
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  64
• Issue:
  3
• NIOSHTIC Number:
  nn:00126678
• Citation:
  Toxicol Appl Pharmacol 1982 Jul; 64(3):541-549
• Contact Point Address:
  Hasan Mukhtar, Department of Dermatology, Case Western Reserve University, 10701 East Boulevard, Cleveland, Ohio 44106 USA
• CAS Registry Number:
  Coal tar (CAS RN 8007-45-2)
• Federal Fiscal Year:
  1982
• Performing Organization:
  Case Western Reserve University, Cleveland, Ohio
• Peer Reviewed:
  True
• Start Date:
  19800929
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19830831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:08b2db6ba25996fa84269ac0d8fa9c9e0b022b7c8001821ffdd5cc9c836e730008322a1b9f6902be9d197624c1fd3044e706033ab28903362d20999e1ca8b289
• Download URL:
  https://stacks.cdc.gov/view/cdc/184588/cdc_184588_DS1.pdf
• File Type:
  [PDF - 715.34 KB ]