Diverse profiles of immunoreactivity in toluene diisocyanate (TDI) asthma.

Details

• Personal Author:
  Bernstein IL ; Brooks, Stuart M. ; Gallagher JS ; Tse CST
• Description:
  Immunoreactivity to mono and diisocyanate protein conjugates was evaluated in fifteen workers with toluene-diisocyanate (584849) (TDI) asthma and seventeen nonexposed volunteers. Intracutaneous skin tests, measurement of specific immunoglobulin to E by leucocyte inhibitory factor (LIF) tests were conducted using conjugates of human serum albumin and TDI (HSA-TDI) or hexamethylene-diisocyanate (822060) (HSA-HDI). Peripheral leucocytes of nine symptomatic workers produced LIF after exposure to HSA-TDI and four of these workers also exhibited LIF activity to HSA-HDI. No LIF activity was detected in nonexposed subjects or in a previously symptomatic worker removed from TDI exposure 7 years prior to testing. [Description provided by NIOSH]
• Subjects:
  Blood Hematologic Tests Immune System Occupational Health Safety Solvents
• Keywords:
  Blood-cells Hematology Immune-reaction Immunological-tests Immunology JOCMA7 NIOSH-Grant NIOSH-Publication Occupational-medicine Organic-solvents
• ISSN:
  0096-1736
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  23
• Issue:
  9
• NIOSHTIC Number:
  nn:00122371
• Citation:
  J Occup Med 1981 Sep; 23(9):610-616
• Contact Point Address:
  Internal Medicine University of Cincinnati 231 Bethesda Avenue Cincinnati, Ohio 45267
• CAS Registry Number:
  Hexamethylene diisocyanate (CAS RN 822-06-0) ; Toluene 2,4-diisocyanate (CAS RN 584-84-9)
• Federal Fiscal Year:
  1981
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  True
• Start Date:
  19780701
• Source Full Name:
  Journal of Occupational Medicine
• End Date:
  19810630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0aaaa5b2b33956faab46c20b79fbd91512712c85b8889dde866c7165b9ca6b88ae114ae5b3cd0b0db2fdf54eb53eb55249ebafe223cc4bca622cf69fff7c3ffe
• Download URL:
  https://stacks.cdc.gov/view/cdc/184539/cdc_184539_DS1.pdf
• File Type:
  [PDF - 656.77 KB ]