Survey of industrial workers for antibodies to toluene diisocyanate.

Details

• Personal Author:
  Karol MH
• Description:
  The occurrence of antibodies to toluene-diisocyanate (584849) (TDI) in selected worker populations was assessed. Serum was collected at 6 month intervals from 103 employees who were exposed for 6 to 24 months to ambient workplace concentrations of 0.2 parts per million or less of TDI. Specific immunoglobulin-E (IgE) antibodies in the blood samples were measured by radioallergosorbent testing using p-tolyl-isocyanate (622582) human serum albumin as antigen. Pulmonary function was measured by spirometer. No tolyl reactive IgE antibodies were detected in serum when workers were exposed to ambient TDI concentrations. Of 20 workers who reported acute exposure, antibody responses developed in 3 of 4 individuals whose exposures were accompanied by immediate respiratory symptoms and spirometric decrease. In contrast, antibody responses developed in only one of nine workers with immediate respiratory symptoms but no spirometric changes. No serologic responses developed in acutely exposed workers who had delayed onset of respiratory symptoms without spirometric changes, or who were asymptomatic at exposure. In persons developing antibodies, an increase, in tolyl reactive IgE was observed within 2 months of exposure. The author suggests that routine serologic screening of workers may be of value in confirming suspected isocyanate exposure and in providing early warning of developing TDI hypersensitivity. [Description provided by NIOSH]
• Subjects:
  Antibodies Hematologic Tests Immune System Occupational Health Safety Solvents Surveys And Questionnaires
• Keywords:
  Antibody Response Health Surveys Hematology Immunology Medical Screening Organic Solvents Screening Methods
• ISSN:
  0096-1736
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  23
• Issue:
  11
• NIOSHTIC Number:
  nn:00119657
• Citation:
  J Occup Med 1981 Nov; 23(11):741-747
• CAS Registry Number:
  4-Methylphenyl isocyanate (CAS RN 622-58-2) ; Toluene 2,4-diisocyanate (CAS RN 584-84-9)
• Federal Fiscal Year:
  1982
• Performing Organization:
  University of Pittsburgh
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational Medicine
• End Date:
  19830430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b16103eb610db238141879fbcc9ef10bc6da968dd78a08f644256c4a27cde6904013a58e3d6e95f3f6b4bf2949f906d8f0d07edcbc7d1614d0291fccab0f60f0
• Download URL:
  https://stacks.cdc.gov/view/cdc/184499/cdc_184499_DS1.pdf
• File Type:
  [PDF - 575.47 KB ]