The neurotoxicity of 5-nonanone: preliminary report.

Details

• Personal Author:
  Bouldin TW ; Graham DG ; Priest JW ; Shifman MA
• Description:
  The neurotoxicity of 5-nonanone (502567) was investigated. Sprague-Dawley-rats were given daily by gavage 150 milligrams per kilogram (mg/kg) of 5-nonanone for 3 weeks followed by 750mg/kg for the next 8 weeks then 1500mg/kg for a final 3 weeks; some of the rats also were given 750mg/kg of methyl-ethyl-ketone (78933) (MEK) twice a week during the 5-nonanone administration period. Rats were killed 1 week after the onset of hind limb weakness or paralysis and neurological tissues were examined. Administration of 5-nonanone, MEK, or 5-nonanone plus MEK caused significant reductions in weight gain. Paralysis onset occurred after 11 and 14 weeks in rats given MEK plus 5-nonanone or 5-nonanone alone, respectively. An orange brown discoloration of the fur was seen on 5-nonanone treated rats. Autopsy revealed giant axonal swelling with neurofilaments in animals given 5-nonanone with or without MEK. The authors note that the neuropathy produced by 5-nonanone is similar to that reported for other gamma diketones. They suggest that omega-1 oxidation of 5-nonanone yields 2,5-nonanedione and possibly 2,5,8-nonanetrione. Any compound that can be metabolized to a gamma diketone is potentially neurotoxic. [Description provided by NIOSH]
• Subjects:
  Chemistry Laboratories Nervous System Nervous System Diseases Occupational Health Safety Solvents
• Keywords:
  Chemical Properties Comparative Toxicology Laboratory Animals Nervous System Disorders Neuropathology Neurophysiological Effects Neurotoxins Organic Solvents
• ISSN:
  0378-4274
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  283-288
• Volume:
  8
• Issue:
  4
• NIOSHTIC Number:
  nn:00118337
• Citation:
  Toxicol Lett 1981 Jun-Jul; 8(4-5):283-288
• CAS Registry Number:
  5-Nonanone (CAS RN 502-56-7) ; Methyl ethyl ketone (CAS RN 78-93-3)
• Federal Fiscal Year:
  1981
• Performing Organization:
  Duke University, Durham, North Carolina
• Peer Reviewed:
  True
• Start Date:
  19790401
• Source Full Name:
  Toxicology Letters
• End Date:
  19980331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f02d4a9cb407d4655c422e31545bf4e3c5a8cbc623e9c87a87f6a4f54612588bee4947d59d79f838d9980b5dbde0bf333f8a6838d4c334e250eebeafa562df30
• Download URL:
  https://stacks.cdc.gov/view/cdc/184485/cdc_184485_DS1.pdf
• File Type:
  [PDF - 609.27 KB ]