Aflatoxin inhibition of viral interferon induction.

Details

• Personal Author:
  Booth JA ; Hahon N ; Stewart JD
• Description:
  The inhibitory effect of aflatoxin on interferon induction by influenza was investigated. Rhesus-monkey cells from the LLC-MK2 line were exposed to 1 to 100 micrograms of aflatoxin-B1 (1162658), aflatoxin-G1 (1165395), aflatoxin-B2 (7220817), or aflatoxin-G2 (7241987), plus 1 milliliter of influenza virus. Interferon induction was determined. Interferon induction was inhibited by all four aflatoxins in the following order of decreasing potency: B1, G1, B2, G2. Aflatoxin-B1 caused the greatest decreases in cell growth and viability in confluent cultures. Cells treated with aflatoxin induced greater influenza virus growth than did normal cells. Aflatoxin did not alter the ability of interferon to aid in the cellular resistance against viral infection, and did not affect viral infectivity or replication. The authors conclude that the inhibition of interferon induction by aflatoxin may be responsible for decreasing resistance to viral infections. [Description provided by NIOSH]
• Subjects:
  Communicable Diseases Hazardous Substances Occupational Health Safety Viral Diseases
• Keywords:
  Cellular-reactions Infectious-diseases Mammalian-cells NIOSH-Author Toxins Viral-diseases
• ISSN:
  0066-4804
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  ALOSH - Appalachian Laboratory for Occupational Safety and Health
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  277-282
• Volume:
  16
• Issue:
  3
• NIOSHTIC Number:
  nn:00118205
• Citation:
  Antimicrob Agents Chemother 1979 Sep; 16(3):277-282
• Contact Point Address:
  Nicholas Hahon, Appalachian Laboratory for Occupational Safety and Health' and Department of Pediatrics, West Virginia University, School of Medicine,2 Morgantown, West Virginia 26505
• CAS Registry Number:
  Aflatoxin B1 (CAS RN 1162-65-8) ; Aflatoxin B2 (CAS RN 7220-81-7) ; Aflatoxin G1 (CAS RN 1165-39-5) ; Aflatoxin G2 (CAS RN 7241-98-7)
• Federal Fiscal Year:
  1979
• Peer Reviewed:
  True
• Source Full Name:
  Antimicrobial Agents and Chemotherapy
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:80f81e431dd7740019ec3d0f40b52715e61ac08e34bc58fc3cd26ffb3836931ff2af33146d3d82c210b83d35317581729bccb3630addfbdb695be3fe100a83cb
• Download URL:
  https://stacks.cdc.gov/view/cdc/184484/cdc_184484_DS1.pdf
• File Type:
  [PDF - 924.34 KB ]